Effects of ethanol and ecstasy on conditioned place preference in the rat

Byron Jones, S. Ben-Hamida, A. Pereira De Vasconcelos, C. Kelche, C. Lazarus, R. Jackisch, J. C. Cassel

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The club drug ecstasy (3,4-methylenedioxymethylamphetamine or MDMA) is often taken recreationally with ethanol (EtOH). We have shown previously that EtOH potentiates the psychomotor effects of MDMA in rats. More recently, we demonstrated in striatal slices that MDMA produced preferential release of serotonin, but when combined with EtOH, the preferential release shifted to dopamine, raising the possibility that administration of EtOH may increase the reward effect of MDMA. To address this possibility, adult male Long-Evans rats were tested for conditioned place preference following treatment with saline, EtOH (0.75 g/kg), MDMA (6.6 mg/kg) or the combination. The only condition that produced a preference for the compartment associated with the drug was that of the drug combination. The current data are in line with anecdotal reports and one study in humans, indicating that EtOH alters the pharmacological effects of MDMA including self reports of enhanced or prolonged euphoria. Thus, administration of EtOH might increase the risk for compulsive use of MDMA, an issue that warrants further study.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalJournal of Psychopharmacology
Volume24
Issue number2
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

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N-Methyl-3,4-methylenedioxyamphetamine
Ethanol
Corpus Striatum
Long Evans Rats
Drug Combinations
Reward
Self Report
Dopamine
Serotonin
Pharmacology

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology

Cite this

Jones, B., Ben-Hamida, S., Pereira De Vasconcelos, A., Kelche, C., Lazarus, C., Jackisch, R., & Cassel, J. C. (2010). Effects of ethanol and ecstasy on conditioned place preference in the rat. Journal of Psychopharmacology, 24(2), 275-279. https://doi.org/10.1177/0269881109102775

Effects of ethanol and ecstasy on conditioned place preference in the rat. / Jones, Byron; Ben-Hamida, S.; Pereira De Vasconcelos, A.; Kelche, C.; Lazarus, C.; Jackisch, R.; Cassel, J. C.

In: Journal of Psychopharmacology, Vol. 24, No. 2, 01.02.2010, p. 275-279.

Research output: Contribution to journalArticle

Jones, B, Ben-Hamida, S, Pereira De Vasconcelos, A, Kelche, C, Lazarus, C, Jackisch, R & Cassel, JC 2010, 'Effects of ethanol and ecstasy on conditioned place preference in the rat', Journal of Psychopharmacology, vol. 24, no. 2, pp. 275-279. https://doi.org/10.1177/0269881109102775
Jones B, Ben-Hamida S, Pereira De Vasconcelos A, Kelche C, Lazarus C, Jackisch R et al. Effects of ethanol and ecstasy on conditioned place preference in the rat. Journal of Psychopharmacology. 2010 Feb 1;24(2):275-279. https://doi.org/10.1177/0269881109102775
Jones, Byron ; Ben-Hamida, S. ; Pereira De Vasconcelos, A. ; Kelche, C. ; Lazarus, C. ; Jackisch, R. ; Cassel, J. C. / Effects of ethanol and ecstasy on conditioned place preference in the rat. In: Journal of Psychopharmacology. 2010 ; Vol. 24, No. 2. pp. 275-279.
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