Effects of Ethanol Exposure during the Third Trimester Equivalent on Neuron Number in Rat Hippocampus and Dentate Gyrus

James R. West, Kristin Hamre, Martin D. Cassell

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

An artificial rearing procedure was used to expose neonatal rats to a formula containing 3.74% ethanol during postnatal days 4 through 10. This treatment produced a mean blood ethanol concentration of 379.8 ± 17.3 mg/dl. When the pups were kitted on the afternoon of postnatal day 10, brain weight to body weight ratio in the ethanol‐exposed rats was reduced 22.4% and 21.5% compared to suckle and pair‐fed controls, respectively. Ethanol exposure also resulted in a 16% reduction of neurons in hippocampal field CA4, compared to controls, but did not produce deficits in fields CA1 or CAS. There was also a 10% increase in the number of neurons (a population of ceto in the midst of a proliferative phase at the time of the exposure) in the granule cefl layer of the dentate gyrus. The ethanol exposure did not affect ceN size in any of the four neuron populations measured. These results suggest, that within the dose and timing parameters examined, ethanol exposure during the third trimester equivalent appears to be preferentially harmful to specific populations of developing neurons.

Original languageEnglish (US)
Pages (from-to)190-197
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1986

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Dentate Gyrus
Third Pregnancy Trimester
Neurons
Rats
Hippocampus
Ethanol
Population
Brain
Blood
Body Weight
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Effects of Ethanol Exposure during the Third Trimester Equivalent on Neuron Number in Rat Hippocampus and Dentate Gyrus. / West, James R.; Hamre, Kristin; Cassell, Martin D.

In: Alcoholism: Clinical and Experimental Research, Vol. 10, No. 2, 01.01.1986, p. 190-197.

Research output: Contribution to journalArticle

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