Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type

A longitudinal study

S. Craft, Samuel Dagogo-Jack, B. V. Wiethop, C. Murphy, R. T. Nevins, S. Fleischman, V. Rice, J. W. Newcomer, P. E. Cryer

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

The effect of hyperglycemia on hormone levels, metabolite levels, and memory performance was examined in 22 subjects with very mild and mild probable dementia of the Alzheimer type (DAT) and in 12 normal elderly adults. Subjects were tested in 3 plasma glucose conditions (fasting baseline, 175 mg/dl, and 225 mg/dl) at initial and 18-month follow-up sessions. Initially, adults with very mild DAT showed memory facilitation and elevations in plasma insulin in the 225-mg/dl glucose condition relative to baseline. At follow-up, very mild DAT patients whose dementia had progressed showed significant decreases in insulin and hyperglycemic memory facilitation. Changes in basal insulin and cortisol levels over time were correlated with memory changes for DAT subjects. These results suggest that glucoregulatory abnormalities may contribute to the pathophysiology of DAT.

Original languageEnglish (US)
Pages (from-to)926-940
Number of pages15
JournalBehavioral Neuroscience
Volume107
Issue number6
DOIs
StatePublished - Dec 1 1993
Externally publishedYes

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Hyperglycemia
Longitudinal Studies
Alzheimer Disease
Hormones
Insulin
Glucose
Dementia
Hydrocortisone
Fasting

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type : A longitudinal study. / Craft, S.; Dagogo-Jack, Samuel; Wiethop, B. V.; Murphy, C.; Nevins, R. T.; Fleischman, S.; Rice, V.; Newcomer, J. W.; Cryer, P. E.

In: Behavioral Neuroscience, Vol. 107, No. 6, 01.12.1993, p. 926-940.

Research output: Contribution to journalArticle

Craft, S, Dagogo-Jack, S, Wiethop, BV, Murphy, C, Nevins, RT, Fleischman, S, Rice, V, Newcomer, JW & Cryer, PE 1993, 'Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study', Behavioral Neuroscience, vol. 107, no. 6, pp. 926-940. https://doi.org/10.1037/0735-7044.107.6.926
Craft, S. ; Dagogo-Jack, Samuel ; Wiethop, B. V. ; Murphy, C. ; Nevins, R. T. ; Fleischman, S. ; Rice, V. ; Newcomer, J. W. ; Cryer, P. E. / Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type : A longitudinal study. In: Behavioral Neuroscience. 1993 ; Vol. 107, No. 6. pp. 926-940.
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