Effects of immobilization stress on the pathogenesis of acute murine toxoplasmosis

Chun C. Chao, Phillip K. Peterson, Gregory A. Filice, Claire Pomeroy, Burt Sharp

Research output: Contribution to journalArticle

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Abstract

Stress modulates a variety of immune responses. We investigated the effects of immobilization stress on the pathogenesis of acute murine toxoplasmosis, an infection in which cell-mediated immunity is of major importance in host defense. Repetitive over-night immobilization beginning 3 days prior to infection enhanced (p < 0.05) the mortality of mice infected with a virulent strain (C56) of Toxoplasma gondii (77% vs 15% mortality in restrained and control mice, respectively). Daily immobilization for 14 days prior to infection abrogated (p < 0.05) the lethal effect of immobilization, suggesting an adaptive mechanism. To explore the effect of immobilization with a less virulent strain, the Me49 strain of T. gondii was studied. Acute infection with T. gondii Me49 resulted in anorexia and weight loss, while spleen size and respiratory burst activity of peritoneal exudate cells were enhanced (p < 0.01). Immobilization (twice daily for 2 h) did not significantly alter survival or other clinical features of acute T. gondii infection. In addition, immobilization suppressed (p < 0.05) phorbol myristate acetate-stimulated release of superoxide anion by peritoneal exudate cells in healthy naive mice, but not in infected mice. These findings indicate that immobilization stress can alter the pathogenesis of acute T. gondii infection in healthy mice, but the effect of this stress paradigm will be influenced, in part, by the timing of the immobilization and the virulence of the strain of T. gondii.

Original languageEnglish (US)
Pages (from-to)162-169
Number of pages8
JournalBrain Behavior and Immunity
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1990

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Toxoplasmosis
Immobilization
Toxoplasma
Exudates and Transudates
Infection
Respiratory Burst
Mortality
Anorexia
Tetradecanoylphorbol Acetate
Cellular Immunity
Superoxides
Virulence
Weight Loss
Spleen

All Science Journal Classification (ASJC) codes

  • Immunology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

Cite this

Effects of immobilization stress on the pathogenesis of acute murine toxoplasmosis. / Chao, Chun C.; Peterson, Phillip K.; Filice, Gregory A.; Pomeroy, Claire; Sharp, Burt.

In: Brain Behavior and Immunity, Vol. 4, No. 2, 01.01.1990, p. 162-169.

Research output: Contribution to journalArticle

Chao, Chun C. ; Peterson, Phillip K. ; Filice, Gregory A. ; Pomeroy, Claire ; Sharp, Burt. / Effects of immobilization stress on the pathogenesis of acute murine toxoplasmosis. In: Brain Behavior and Immunity. 1990 ; Vol. 4, No. 2. pp. 162-169.
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