Effects of indomethacin on cardiovascular hemodynamics of goats in hemorrhagic shock

Charles Leffler, T. L. Tyler, S. Cassin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The authors examined effects of indomethacin, meclofenamate and prostaglandin E1 on systemic arterial pressure, heart rate, cardiac output, and systemic vascular resistance of anesthetized juvenile goats in severe hemorrhagic shock. Hemorrhagic shock was characterized by low systemic arterial pressure, decreased vascular resistance, and reduction in cardiac output. In acute experiments, indomethacin (3.4 mg/kg) attenuated the systemic hypotentsion of hemorrhagic shock. The increase in systemic arterial pressure following treatment with indomethacin was the result of increased systemic vascular resistance. Systemic arterial pressure, heart rate, and cardiac output fell during intravenous prostaglandin E1 infusions (3 μg/kg/min for 5 min) in both controls and goats in shock. The effects of prostaglandin E1 were more pronounced and prolonged in goats that had undergone the hemorrhagic-shock-producing procedure followed by indomethacin than in control animals treated with indomethacin but not hemorrhaged. Not only was meclofenamate less effective than indomethacin in increasing the systemic arterial pressures of goats in this type of hemorrhagic shock, but also it attenuated the pressor effects of indomethacin. Substances synthesized via prostaglandin fatty acid cyclo-oxygenase may be involved in the systemic hypotension that is characteristic of hemorrhagic shock.

Original languageEnglish (US)
Pages (from-to)299-310
Number of pages12
JournalCirculatory Shock
Volume5
Issue number3
StatePublished - Dec 1 1978
Externally publishedYes

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Hemorrhagic Shock
Goats
Indomethacin
Hemodynamics
Arterial Pressure
Alprostadil
Meclofenamic Acid
Cardiac Output
Vascular Resistance
Heart Rate
Prostaglandin-Endoperoxide Synthases
Hypotension
Prostaglandins
Shock

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of indomethacin on cardiovascular hemodynamics of goats in hemorrhagic shock. / Leffler, Charles; Tyler, T. L.; Cassin, S.

In: Circulatory Shock, Vol. 5, No. 3, 01.12.1978, p. 299-310.

Research output: Contribution to journalArticle

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