Effects of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory of rats

Leila Azimi, Ali Pourmotabbed, Mohammad Rasool Ghadami, Seyed Ershad Nedaei, Tayebeh Pourmotabbed

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective(s): Cyclooxygenases (COXs) are known to play some roles in physiological mechanisms related to learning and memory. Since sodium salicylate is an inhibitor of COX, we have evaluated the effect of peripheral and intrahippocampal administration of sodium salicylate on spatial learning and memory in male rats. Materials and Methods: Male rats were studied in two groups; the first group received different intraperitoneal (i.p.) sodium salicylate doses (0, 200, 300, and 400 mg/kg) and the second group received intra-hippocampal doses of the drug (0, 30, 50, and 100 μg/0.5 μl/side). The spatial performance of rats was tested using Morris water maze (MWM) task. The spatial learning and memory parameters were analyzed using ANOVA. Results: Peripheral and intra-hippocampal administration of sodium salicylate did not lead to a statistically significant change in the mean time (escape latency), and also the distance traveled for finding the hidden platform during the training days, compared with the control group. But at the probe trial, the percentage of time spent in the target quadrant by rats which received the highest doses of drug significantly increased. Conclusion: We found that both peripheral and intra-hippocampal administration of sodium salicylate facilitates the process of spatial memory consolidation in the MWM.

Original languageEnglish (US)
Pages (from-to)709-718
Number of pages10
JournalIranian Journal of Basic Medical Sciences
Volume15
Issue number2
StatePublished - Mar 1 2012

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Sodium Salicylate
Rats
Data storage equipment
Computer peripheral equipment
Cyclooxygenase Inhibitors
Water
Prostaglandin-Endoperoxide Synthases
Analysis of variance (ANOVA)
Pharmaceutical Preparations
Consolidation
Analysis of Variance
Spatial Memory
Spatial Learning
Learning
Control Groups

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Immunology and Microbiology(all)
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Effects of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory of rats. / Azimi, Leila; Pourmotabbed, Ali; Ghadami, Mohammad Rasool; Nedaei, Seyed Ershad; Pourmotabbed, Tayebeh.

In: Iranian Journal of Basic Medical Sciences, Vol. 15, No. 2, 01.03.2012, p. 709-718.

Research output: Contribution to journalArticle

Azimi, Leila ; Pourmotabbed, Ali ; Ghadami, Mohammad Rasool ; Nedaei, Seyed Ershad ; Pourmotabbed, Tayebeh. / Effects of peripheral and intra-hippocampal administration of sodium salicylate on spatial learning and memory of rats. In: Iranian Journal of Basic Medical Sciences. 2012 ; Vol. 15, No. 2. pp. 709-718.
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