Effects of peripheral immune activation on social behavior and adrenocortical activity in aggressive mice: Genotype-environment interactions

Douglas A. Granger, Kathryn E. Hood, Sandra C. Ikeda, Cheryl L. Reed, Byron Jones, Michelle L. Block

Research output: Contribution to journalArticle

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Abstract

To explore genetic-developmental differences in the biobehavioral effects of induced illness, males from two lines of mice sc lectively bred for high or low levels of aggressive behavior were injected with endotoxin (Escherichia coli, LPS: 0.25 mg/kg, 1.25 mg/kg, or 2.5 mg, i.p.) or saline. Body temperature, weight, and locomotor activity were monitored immediately before and 8 and 24 hr after injection. Twenty-four hours after injection, social behaviors were assessed in a 10-min dyadic test, and hypothalamus, spleen, and serum were collected. In both lines, endotoxin treatment increased behavioral immobility ("freezing") and decreased social exploration. Other effects showed line differences: Males from the high-aggressive line had a lower threshold to endotoxin-induced effects on body temperature, weight loss, spleen weight, and corticosterone. Social reactivity (startle response to mild social investigation) increased in the high-aggressive line and decreased in the low-aggressive line after treatment. In the high-aggressive line only, endotoxin decreased attack frequency and increased latency to attack. The interactions between selected line (genotype) and endotoxin treatment (environment) demonstrate that genetic-developmental differences in social and aggressive behavior may indicate the extent to which immune stimuli (e.g., bacteria, viruses, cytokines) function as "biobehavioral stressors." Aggr. Behav. 23:93-105, 1997.

Original languageEnglish (US)
Pages (from-to)93-105
Number of pages13
JournalAggressive Behavior
Volume23
Issue number2
StatePublished - Dec 1 1997
Externally publishedYes

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Social Behavior
Endotoxins
Genotype
Body Temperature
Startle Reflex
Spleen
Body Weight
Injections
Locomotion
Corticosterone
Freezing
Hypothalamus
Weight Loss
Therapeutics
Cytokines
Viruses
Bacteria
Weights and Measures
Interaction
Activation

All Science Journal Classification (ASJC) codes

  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Psychology(all)

Cite this

Effects of peripheral immune activation on social behavior and adrenocortical activity in aggressive mice : Genotype-environment interactions. / Granger, Douglas A.; Hood, Kathryn E.; Ikeda, Sandra C.; Reed, Cheryl L.; Jones, Byron; Block, Michelle L.

In: Aggressive Behavior, Vol. 23, No. 2, 01.12.1997, p. 93-105.

Research output: Contribution to journalArticle

Granger, Douglas A. ; Hood, Kathryn E. ; Ikeda, Sandra C. ; Reed, Cheryl L. ; Jones, Byron ; Block, Michelle L. / Effects of peripheral immune activation on social behavior and adrenocortical activity in aggressive mice : Genotype-environment interactions. In: Aggressive Behavior. 1997 ; Vol. 23, No. 2. pp. 93-105.
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