Effects of phenylpropanolamine on withdrawal symptoms

Robert Klesges, L. M. Klesges, M. DeBon, M. L. Shelton, T. R. Isbell, M. L. Klem

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A prior report (Klesges et al. 1990) suggested that phenylpropanolamine (PPA) was successful in reducing the smoking withdrawal symptom of weight gain in a sample of women. The current investigation evaluates whether the effects of phenylpropanolamine (PPA; up to 10/day PPA gums) on withdrawal symptoms associated with smoking cessation are specific to weight and weight-related symptoms or whether PPA alleviates withdrawal in general. One hundred and seven adult smokers (56 men, 51 women) were randomly assigned, in this double-blind trial, to chew either 8.33 mg phenylpropanolamine gum or a placebo gum. Subjects were then aided to quit smoking for 4 weeks. PPA did not enhance cessation rates. Results from the 47 subjects who successfully quit smoking indicated that postcessation weight gain and ratings of hunger were significantly reduced in both men and women for those assigned to the PPA group relative to the placebo group. Overall, no effects of PPA relative to placebo were observed for other smoking-related withdrawal symptoms. Thus, although PPA appears to reduce weight gain and alleviate weight-related symptoms, no effects on other withdrawal symptoms were observed. Future research directions are suggested.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalPsychopharmacology
Volume119
Issue number1
DOIs
StatePublished - May 1 1995

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Phenylpropanolamine
Substance Withdrawal Syndrome
Gingiva
Smoking
Weight Gain
Placebos
Weights and Measures
Hunger
Smoking Cessation

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Klesges, R., Klesges, L. M., DeBon, M., Shelton, M. L., Isbell, T. R., & Klem, M. L. (1995). Effects of phenylpropanolamine on withdrawal symptoms. Psychopharmacology, 119(1), 85-91. https://doi.org/10.1007/BF02246058

Effects of phenylpropanolamine on withdrawal symptoms. / Klesges, Robert; Klesges, L. M.; DeBon, M.; Shelton, M. L.; Isbell, T. R.; Klem, M. L.

In: Psychopharmacology, Vol. 119, No. 1, 01.05.1995, p. 85-91.

Research output: Contribution to journalArticle

Klesges, R, Klesges, LM, DeBon, M, Shelton, ML, Isbell, TR & Klem, ML 1995, 'Effects of phenylpropanolamine on withdrawal symptoms', Psychopharmacology, vol. 119, no. 1, pp. 85-91. https://doi.org/10.1007/BF02246058
Klesges R, Klesges LM, DeBon M, Shelton ML, Isbell TR, Klem ML. Effects of phenylpropanolamine on withdrawal symptoms. Psychopharmacology. 1995 May 1;119(1):85-91. https://doi.org/10.1007/BF02246058
Klesges, Robert ; Klesges, L. M. ; DeBon, M. ; Shelton, M. L. ; Isbell, T. R. ; Klem, M. L. / Effects of phenylpropanolamine on withdrawal symptoms. In: Psychopharmacology. 1995 ; Vol. 119, No. 1. pp. 85-91.
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