Effects of prostaglandins and prostaglandin precursors on the arterial pressure of the bullfrog, Rana catesbiana

Charles Leffler, Robert C. Hanson, Edward G. Schneider

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Effects of prostaglandin precursors, prostaglandins, and cyclooxygenase inhibitors upon arterial pressures of unanesthetized bullfrogs were determined. 1. The mean arterial pressure of the bullfrogs was 32 ± 2 mm Hg and was not affected by indomethacin. 2. Intravenous arachidonic acid decreased arterial pressure, producing a 40% decrease at 3 mg/kg per min for 3 min. Arachidonic acid responses were attenuated by indomethacin or ETYA. 3. Intravenous PGE2, PGI2, and PGF all decreased arterial pressure. PGE2 and PGI2 were similar in potency, with PGF being less potent. All three were more potent than arachidonic acid. 4. Endogenous arterial PG concentrations were less than 0.04, 0.28, and 13 ng/ml of PGE2, PGF, and PGI2, respectively.

Original languageEnglish (US)
Pages (from-to)199-202
Number of pages4
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume66
Issue number2
DOIs
StatePublished - Jan 1 1980

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Ranidae
Rana catesbeiana
Prostaglandins
Dinoprost
Arterial Pressure
Epoprostenol
Dinoprostone
Arachidonic Acid
Indomethacin
5,8,11,14-Eicosatetraynoic Acid
Prostaglandin Antagonists
Cyclooxygenase Inhibitors
Prostaglandin-Endoperoxide Synthases

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Effects of prostaglandins and prostaglandin precursors on the arterial pressure of the bullfrog, Rana catesbiana. / Leffler, Charles; Hanson, Robert C.; Schneider, Edward G.

In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 66, No. 2, 01.01.1980, p. 199-202.

Research output: Contribution to journalArticle

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AB - Effects of prostaglandin precursors, prostaglandins, and cyclooxygenase inhibitors upon arterial pressures of unanesthetized bullfrogs were determined. 1. The mean arterial pressure of the bullfrogs was 32 ± 2 mm Hg and was not affected by indomethacin. 2. Intravenous arachidonic acid decreased arterial pressure, producing a 40% decrease at 3 mg/kg per min for 3 min. Arachidonic acid responses were attenuated by indomethacin or ETYA. 3. Intravenous PGE2, PGI2, and PGF2α all decreased arterial pressure. PGE2 and PGI2 were similar in potency, with PGF2α being less potent. All three were more potent than arachidonic acid. 4. Endogenous arterial PG concentrations were less than 0.04, 0.28, and 13 ng/ml of PGE2, PGF2α, and PGI2, respectively.

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