Effects of prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats during normoxia and hypoxia

T. Tyler, Charles Leffler, R. Wallis, S. Cassin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Effects of exogenous prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats were investigated during normoxia and hypoxia. Pulmonary arterial infusion of prostaglandins E1 and E2 decreased pulmonary vascular resistance 20% and 14%, respectively, without systemic effects. Prostaglandin E1 abolished the pulmonary pressor response to hypoxia. Prostaglandin E2 was less effective in counteracting this hypoxic response. The increased pulmonary vascular resistance and augmented response to hypoxia following indomethacin administration was reversed by prostaglandin E1. Infusion of prostaglandin E1 directly into the pulmonary circulation may be of benefit to the distressed newborn with elevated pulmonary vascular resistance.

Original languageEnglish (US)
Pages (from-to)963-970
Number of pages8
JournalProstaglandins
Volume10
Issue number6
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

Fingerprint

Pulmonary Circulation
Alprostadil
Prostaglandins E
Goats
Vascular Resistance
Dinoprostone
Lung
Indomethacin
Hypoxia

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

Cite this

Effects of prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats during normoxia and hypoxia. / Tyler, T.; Leffler, Charles; Wallis, R.; Cassin, S.

In: Prostaglandins, Vol. 10, No. 6, 01.01.1975, p. 963-970.

Research output: Contribution to journalArticle

@article{7b29033e7d5e4e2aaf2ddc14f581efae,
title = "Effects of prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats during normoxia and hypoxia",
abstract = "Effects of exogenous prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats were investigated during normoxia and hypoxia. Pulmonary arterial infusion of prostaglandins E1 and E2 decreased pulmonary vascular resistance 20{\%} and 14{\%}, respectively, without systemic effects. Prostaglandin E1 abolished the pulmonary pressor response to hypoxia. Prostaglandin E2 was less effective in counteracting this hypoxic response. The increased pulmonary vascular resistance and augmented response to hypoxia following indomethacin administration was reversed by prostaglandin E1. Infusion of prostaglandin E1 directly into the pulmonary circulation may be of benefit to the distressed newborn with elevated pulmonary vascular resistance.",
author = "T. Tyler and Charles Leffler and R. Wallis and S. Cassin",
year = "1975",
month = "1",
day = "1",
doi = "10.1016/S0090-6980(75)80043-8",
language = "English (US)",
volume = "10",
pages = "963--970",
journal = "Prostaglandins",
issn = "0090-6980",
publisher = "Elsevier BV",
number = "6",

}

TY - JOUR

T1 - Effects of prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats during normoxia and hypoxia

AU - Tyler, T.

AU - Leffler, Charles

AU - Wallis, R.

AU - Cassin, S.

PY - 1975/1/1

Y1 - 1975/1/1

N2 - Effects of exogenous prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats were investigated during normoxia and hypoxia. Pulmonary arterial infusion of prostaglandins E1 and E2 decreased pulmonary vascular resistance 20% and 14%, respectively, without systemic effects. Prostaglandin E1 abolished the pulmonary pressor response to hypoxia. Prostaglandin E2 was less effective in counteracting this hypoxic response. The increased pulmonary vascular resistance and augmented response to hypoxia following indomethacin administration was reversed by prostaglandin E1. Infusion of prostaglandin E1 directly into the pulmonary circulation may be of benefit to the distressed newborn with elevated pulmonary vascular resistance.

AB - Effects of exogenous prostaglandins of the E-series on pulmonary and systemic circulations of newborn goats were investigated during normoxia and hypoxia. Pulmonary arterial infusion of prostaglandins E1 and E2 decreased pulmonary vascular resistance 20% and 14%, respectively, without systemic effects. Prostaglandin E1 abolished the pulmonary pressor response to hypoxia. Prostaglandin E2 was less effective in counteracting this hypoxic response. The increased pulmonary vascular resistance and augmented response to hypoxia following indomethacin administration was reversed by prostaglandin E1. Infusion of prostaglandin E1 directly into the pulmonary circulation may be of benefit to the distressed newborn with elevated pulmonary vascular resistance.

UR - http://www.scopus.com/inward/record.url?scp=0016730734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016730734&partnerID=8YFLogxK

U2 - 10.1016/S0090-6980(75)80043-8

DO - 10.1016/S0090-6980(75)80043-8

M3 - Article

VL - 10

SP - 963

EP - 970

JO - Prostaglandins

JF - Prostaglandins

SN - 0090-6980

IS - 6

ER -