Effects of ranitidine and cimetidine on plasma lipoproteins in healthy subjects

Colin Howden, C. D. Fletcher, E. Farish, J. L. Reid

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Serum lipoproteins were monitored in 24 healthy subjects receiving either ranitidine or cimetidine for four weeks. Ranitidine produced a significant (P < .05) reduction in high-density lipoprotein (HDL)-cholesterol in both men and women. Cimetidine caused a nonsignificant increase in HDL-cholesterol and a reduction in LDL-cholesterol that was significant (P < .05) only in women. As these drugs had opposite effects on HDL-cholesterol levels, the mechanism of action is unlikely to be medicated by H2-receptor blockade.

Original languageEnglish (US)
Pages (from-to)97-99
Number of pages3
JournalJournal of Clinical Pharmacology
Volume26
Issue number2
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Ranitidine
Cimetidine
HDL Cholesterol
Lipoproteins
Healthy Volunteers
Histamine H2 Receptors
LDL Cholesterol
Serum
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Effects of ranitidine and cimetidine on plasma lipoproteins in healthy subjects. / Howden, Colin; Fletcher, C. D.; Farish, E.; Reid, J. L.

In: Journal of Clinical Pharmacology, Vol. 26, No. 2, 01.01.1986, p. 97-99.

Research output: Contribution to journalArticle

Howden, Colin ; Fletcher, C. D. ; Farish, E. ; Reid, J. L. / Effects of ranitidine and cimetidine on plasma lipoproteins in healthy subjects. In: Journal of Clinical Pharmacology. 1986 ; Vol. 26, No. 2. pp. 97-99.
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