Effects of residual stenosis on infarct size and regional transmural myocardial blood flow after reperfusion

Jack L. Wilson, K Ramanathan, Leslie A. Ingram, David M. Mirvis

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This study in dogs was designed to determine the effects of residual stenosis on infarct size and on the transmural distribution of coronary flow in the central and peripheral ischemic perfusion bed. A plastic shunt containing a Doppler flow probe was inserted between the left anterior descending coronary artery and the subclavian artery. The dogs were divided into two groups. Group 1 (N = 7) underwent total shunt occlusion for 2 hours followed by reperfusion at 50% of control flow for 2 hours. Group 2 (N = 8) underwent 2 hours of total occlusion followed by 2 hours of total reperfusion. Regional blood flow was measured by radiolabel microspheres, and infarct areas were quantitated with triphenyl tetrazolium chloride staining. Infarct sizes expressed as a percentage of the left ventricle or as a percentage of perfusion territory were significantly (p < 0.05) smaller in animals with total repefusion (group 2) than in dogs with partial reperfusion (group 1). Endocardial flows in the central infarct zone were significantly higher in dogs with total reperfusion than was observed with partial reperfusion; epicardial flows were not significantly different. In the peripheral region both endocardial flows and epicardial flows with total reperfusion were significantly higher than with partial reperfusion. These studies suggest that residual stenosis after thrombolysis may increase infarct size and reduce endocardial flow in the central infarct zone and transmural flow in the peripheral zone.

Original languageEnglish (US)
Pages (from-to)1523-1529
Number of pages7
JournalAmerican Heart Journal
Volume116
Issue number6 PART 1
DOIs
StatePublished - Jan 1 1988

Fingerprint

Reperfusion
Pathologic Constriction
Dogs
Perfusion
Subclavian Artery
Regional Blood Flow
Microspheres
Plastics
Heart Ventricles
Chlorides
Coronary Vessels
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Effects of residual stenosis on infarct size and regional transmural myocardial blood flow after reperfusion. / Wilson, Jack L.; Ramanathan, K; Ingram, Leslie A.; Mirvis, David M.

In: American Heart Journal, Vol. 116, No. 6 PART 1, 01.01.1988, p. 1523-1529.

Research output: Contribution to journalArticle

Wilson, Jack L. ; Ramanathan, K ; Ingram, Leslie A. ; Mirvis, David M. / Effects of residual stenosis on infarct size and regional transmural myocardial blood flow after reperfusion. In: American Heart Journal. 1988 ; Vol. 116, No. 6 PART 1. pp. 1523-1529.
@article{39919b856ea24f5a8cbfe6e62af70168,
title = "Effects of residual stenosis on infarct size and regional transmural myocardial blood flow after reperfusion",
abstract = "This study in dogs was designed to determine the effects of residual stenosis on infarct size and on the transmural distribution of coronary flow in the central and peripheral ischemic perfusion bed. A plastic shunt containing a Doppler flow probe was inserted between the left anterior descending coronary artery and the subclavian artery. The dogs were divided into two groups. Group 1 (N = 7) underwent total shunt occlusion for 2 hours followed by reperfusion at 50{\%} of control flow for 2 hours. Group 2 (N = 8) underwent 2 hours of total occlusion followed by 2 hours of total reperfusion. Regional blood flow was measured by radiolabel microspheres, and infarct areas were quantitated with triphenyl tetrazolium chloride staining. Infarct sizes expressed as a percentage of the left ventricle or as a percentage of perfusion territory were significantly (p < 0.05) smaller in animals with total repefusion (group 2) than in dogs with partial reperfusion (group 1). Endocardial flows in the central infarct zone were significantly higher in dogs with total reperfusion than was observed with partial reperfusion; epicardial flows were not significantly different. In the peripheral region both endocardial flows and epicardial flows with total reperfusion were significantly higher than with partial reperfusion. These studies suggest that residual stenosis after thrombolysis may increase infarct size and reduce endocardial flow in the central infarct zone and transmural flow in the peripheral zone.",
author = "Wilson, {Jack L.} and K Ramanathan and Ingram, {Leslie A.} and Mirvis, {David M.}",
year = "1988",
month = "1",
day = "1",
doi = "10.1016/0002-8703(88)90738-7",
language = "English (US)",
volume = "116",
pages = "1523--1529",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "6 PART 1",

}

TY - JOUR

T1 - Effects of residual stenosis on infarct size and regional transmural myocardial blood flow after reperfusion

AU - Wilson, Jack L.

AU - Ramanathan, K

AU - Ingram, Leslie A.

AU - Mirvis, David M.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - This study in dogs was designed to determine the effects of residual stenosis on infarct size and on the transmural distribution of coronary flow in the central and peripheral ischemic perfusion bed. A plastic shunt containing a Doppler flow probe was inserted between the left anterior descending coronary artery and the subclavian artery. The dogs were divided into two groups. Group 1 (N = 7) underwent total shunt occlusion for 2 hours followed by reperfusion at 50% of control flow for 2 hours. Group 2 (N = 8) underwent 2 hours of total occlusion followed by 2 hours of total reperfusion. Regional blood flow was measured by radiolabel microspheres, and infarct areas were quantitated with triphenyl tetrazolium chloride staining. Infarct sizes expressed as a percentage of the left ventricle or as a percentage of perfusion territory were significantly (p < 0.05) smaller in animals with total repefusion (group 2) than in dogs with partial reperfusion (group 1). Endocardial flows in the central infarct zone were significantly higher in dogs with total reperfusion than was observed with partial reperfusion; epicardial flows were not significantly different. In the peripheral region both endocardial flows and epicardial flows with total reperfusion were significantly higher than with partial reperfusion. These studies suggest that residual stenosis after thrombolysis may increase infarct size and reduce endocardial flow in the central infarct zone and transmural flow in the peripheral zone.

AB - This study in dogs was designed to determine the effects of residual stenosis on infarct size and on the transmural distribution of coronary flow in the central and peripheral ischemic perfusion bed. A plastic shunt containing a Doppler flow probe was inserted between the left anterior descending coronary artery and the subclavian artery. The dogs were divided into two groups. Group 1 (N = 7) underwent total shunt occlusion for 2 hours followed by reperfusion at 50% of control flow for 2 hours. Group 2 (N = 8) underwent 2 hours of total occlusion followed by 2 hours of total reperfusion. Regional blood flow was measured by radiolabel microspheres, and infarct areas were quantitated with triphenyl tetrazolium chloride staining. Infarct sizes expressed as a percentage of the left ventricle or as a percentage of perfusion territory were significantly (p < 0.05) smaller in animals with total repefusion (group 2) than in dogs with partial reperfusion (group 1). Endocardial flows in the central infarct zone were significantly higher in dogs with total reperfusion than was observed with partial reperfusion; epicardial flows were not significantly different. In the peripheral region both endocardial flows and epicardial flows with total reperfusion were significantly higher than with partial reperfusion. These studies suggest that residual stenosis after thrombolysis may increase infarct size and reduce endocardial flow in the central infarct zone and transmural flow in the peripheral zone.

UR - http://www.scopus.com/inward/record.url?scp=0024233079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024233079&partnerID=8YFLogxK

U2 - 10.1016/0002-8703(88)90738-7

DO - 10.1016/0002-8703(88)90738-7

M3 - Article

C2 - 3195437

AN - SCOPUS:0024233079

VL - 116

SP - 1523

EP - 1529

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 6 PART 1

ER -