Effects of sex steroids on bones and muscles

Similarities, parallels, and putative interactions in health and disease

James Carson, Stavros C. Manolagas

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Estrogens and androgens influence the growth and maintenance of bones and muscles and are responsible for their sexual dimorphism. A decline in their circulating levels leads to loss of mass and functional integrity in both tissues. In the article, we highlight the similarities of the molecular and cellular mechanisms of action of sex steroids in the two tissues; the commonality of a critical role of mechanical forces on tissue mass and function; emerging evidence for an interplay between mechanical forces and hormonal and growth factor signals in both bones and muscles; as well as the current state of evidence for or against a cross-talk between muscles and bone. In addition, we review evidence for the parallels in the development of osteoporosis and sarcopenia with advancing age and the potential common mechanisms responsible for the age-dependent involution of these two tissues. Lastly, we discuss the striking difference in the availability of several drug therapies for the prevention and treatment of osteoporosis, as compared to none for sarcopenia.

Original languageEnglish (US)
Pages (from-to)67-78
Number of pages12
JournalBone
Volume80
DOIs
StatePublished - Nov 1 2015

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Steroids
Sarcopenia
Bone and Bones
Muscles
Health
Osteoporosis
Bone Development
Sex Characteristics
Androgens
Intercellular Signaling Peptides and Proteins
Estrogens
Maintenance
Drug Therapy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Cite this

Effects of sex steroids on bones and muscles : Similarities, parallels, and putative interactions in health and disease. / Carson, James; Manolagas, Stavros C.

In: Bone, Vol. 80, 01.11.2015, p. 67-78.

Research output: Contribution to journalArticle

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