Effects of smoking on the genetic risk of obesity: The population architecture using genomics and epidemiology study

Megan D. Fesinmeyer, Kari E. North, Unhee Lim, Petra Bůžková, Dana C. Crawford, Jeffrey Haessler, Myron D. Gross, Jay H. Fowke, Robert Goodloe, Shelley Ann Love, Misa Graff, Christopher S. Carlson, Lewis H. Kuller, Tara C. Matise, Ching Ping Hong, Brian E. Henderson, Melissa Allen, Rebecca R. Rohde, Ping Mayo, Nathalie Schnetz-BoutaudKristine R. Monroe, Marylyn D. Ritchie, Ross L. Prentice, Lawrence N. Kolonel, Jo Ann E. Manson, James Pankow, Lucia A. Hindorff, Nora Franceschini, Lynne R. Wilkens, Christopher A. Haiman, Loic Le Marchand, Ulrike Peters

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored.Methods: As part of the 'Population Architecture using Genomics and Epidemiology (PAGE)' Consortium, we investigated interaction between genetic risk factors associated with BMI and smoking for 10 single nucleotide polymorphisms (SNPs) previously identified in genome-wide association studies. We included 6 studies with a total of 56,466 subjects (16,750 African Americans (AA) and 39,716 European Americans (EA)). We assessed effect modification by testing an interaction term for each SNP and smoking (current vs. former/never) in the linear regression and by stratified analyses.Results: We did not observe strong evidence for interactions and only observed two interactions with p-values <0.1: for rs6548238/TMEM18, the risk allele (C) was associated with BMI only among AA females who were former/never smokers (β = 0.018, p = 0.002), vs. current smokers (β = 0.001, p = 0.95, pinteraction = 0.10). For rs9939609/FTO, the A allele was more strongly associated with BMI among current smoker EA females (β = 0.017, p = 3.5x10-5), vs. former/never smokers (β = 0.006, p = 0.05, pinteraction = 0.08).Conclusions: These analyses provide limited evidence that smoking status may modify genetic effects of previously identified genetic risk factors for BMI. Larger studies are needed to follow up our results.Clinical Trial Registration: NCT00000611.

Original languageEnglish (US)
Article number6
JournalBMC Medical Genetics
Volume14
Issue number1
DOIs
StatePublished - Jan 11 2013

Fingerprint

Genomics
Epidemiology
Body Mass Index
Obesity
Smoking
Population
African Americans
Single Nucleotide Polymorphism
Alleles
Genome-Wide Association Study
Linear Models
Regression Analysis
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Fesinmeyer, M. D., North, K. E., Lim, U., Bůžková, P., Crawford, D. C., Haessler, J., ... Peters, U. (2013). Effects of smoking on the genetic risk of obesity: The population architecture using genomics and epidemiology study. BMC Medical Genetics, 14(1), [6]. https://doi.org/10.1186/1471-2350-14-6

Effects of smoking on the genetic risk of obesity : The population architecture using genomics and epidemiology study. / Fesinmeyer, Megan D.; North, Kari E.; Lim, Unhee; Bůžková, Petra; Crawford, Dana C.; Haessler, Jeffrey; Gross, Myron D.; Fowke, Jay H.; Goodloe, Robert; Love, Shelley Ann; Graff, Misa; Carlson, Christopher S.; Kuller, Lewis H.; Matise, Tara C.; Hong, Ching Ping; Henderson, Brian E.; Allen, Melissa; Rohde, Rebecca R.; Mayo, Ping; Schnetz-Boutaud, Nathalie; Monroe, Kristine R.; Ritchie, Marylyn D.; Prentice, Ross L.; Kolonel, Lawrence N.; Manson, Jo Ann E.; Pankow, James; Hindorff, Lucia A.; Franceschini, Nora; Wilkens, Lynne R.; Haiman, Christopher A.; Le Marchand, Loic; Peters, Ulrike.

In: BMC Medical Genetics, Vol. 14, No. 1, 6, 11.01.2013.

Research output: Contribution to journalArticle

Fesinmeyer, MD, North, KE, Lim, U, Bůžková, P, Crawford, DC, Haessler, J, Gross, MD, Fowke, JH, Goodloe, R, Love, SA, Graff, M, Carlson, CS, Kuller, LH, Matise, TC, Hong, CP, Henderson, BE, Allen, M, Rohde, RR, Mayo, P, Schnetz-Boutaud, N, Monroe, KR, Ritchie, MD, Prentice, RL, Kolonel, LN, Manson, JAE, Pankow, J, Hindorff, LA, Franceschini, N, Wilkens, LR, Haiman, CA, Le Marchand, L & Peters, U 2013, 'Effects of smoking on the genetic risk of obesity: The population architecture using genomics and epidemiology study', BMC Medical Genetics, vol. 14, no. 1, 6. https://doi.org/10.1186/1471-2350-14-6
Fesinmeyer, Megan D. ; North, Kari E. ; Lim, Unhee ; Bůžková, Petra ; Crawford, Dana C. ; Haessler, Jeffrey ; Gross, Myron D. ; Fowke, Jay H. ; Goodloe, Robert ; Love, Shelley Ann ; Graff, Misa ; Carlson, Christopher S. ; Kuller, Lewis H. ; Matise, Tara C. ; Hong, Ching Ping ; Henderson, Brian E. ; Allen, Melissa ; Rohde, Rebecca R. ; Mayo, Ping ; Schnetz-Boutaud, Nathalie ; Monroe, Kristine R. ; Ritchie, Marylyn D. ; Prentice, Ross L. ; Kolonel, Lawrence N. ; Manson, Jo Ann E. ; Pankow, James ; Hindorff, Lucia A. ; Franceschini, Nora ; Wilkens, Lynne R. ; Haiman, Christopher A. ; Le Marchand, Loic ; Peters, Ulrike. / Effects of smoking on the genetic risk of obesity : The population architecture using genomics and epidemiology study. In: BMC Medical Genetics. 2013 ; Vol. 14, No. 1.
@article{f201df39d8904353a7b27d9e916bf41c,
title = "Effects of smoking on the genetic risk of obesity: The population architecture using genomics and epidemiology study",
abstract = "Background: Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored.Methods: As part of the 'Population Architecture using Genomics and Epidemiology (PAGE)' Consortium, we investigated interaction between genetic risk factors associated with BMI and smoking for 10 single nucleotide polymorphisms (SNPs) previously identified in genome-wide association studies. We included 6 studies with a total of 56,466 subjects (16,750 African Americans (AA) and 39,716 European Americans (EA)). We assessed effect modification by testing an interaction term for each SNP and smoking (current vs. former/never) in the linear regression and by stratified analyses.Results: We did not observe strong evidence for interactions and only observed two interactions with p-values <0.1: for rs6548238/TMEM18, the risk allele (C) was associated with BMI only among AA females who were former/never smokers (β = 0.018, p = 0.002), vs. current smokers (β = 0.001, p = 0.95, pinteraction = 0.10). For rs9939609/FTO, the A allele was more strongly associated with BMI among current smoker EA females (β = 0.017, p = 3.5x10-5), vs. former/never smokers (β = 0.006, p = 0.05, pinteraction = 0.08).Conclusions: These analyses provide limited evidence that smoking status may modify genetic effects of previously identified genetic risk factors for BMI. Larger studies are needed to follow up our results.Clinical Trial Registration: NCT00000611.",
author = "Fesinmeyer, {Megan D.} and North, {Kari E.} and Unhee Lim and Petra Bůžkov{\'a} and Crawford, {Dana C.} and Jeffrey Haessler and Gross, {Myron D.} and Fowke, {Jay H.} and Robert Goodloe and Love, {Shelley Ann} and Misa Graff and Carlson, {Christopher S.} and Kuller, {Lewis H.} and Matise, {Tara C.} and Hong, {Ching Ping} and Henderson, {Brian E.} and Melissa Allen and Rohde, {Rebecca R.} and Ping Mayo and Nathalie Schnetz-Boutaud and Monroe, {Kristine R.} and Ritchie, {Marylyn D.} and Prentice, {Ross L.} and Kolonel, {Lawrence N.} and Manson, {Jo Ann E.} and James Pankow and Hindorff, {Lucia A.} and Nora Franceschini and Wilkens, {Lynne R.} and Haiman, {Christopher A.} and {Le Marchand}, Loic and Ulrike Peters",
year = "2013",
month = "1",
day = "11",
doi = "10.1186/1471-2350-14-6",
language = "English (US)",
volume = "14",
journal = "BMC Medical Genetics",
issn = "1471-2350",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Effects of smoking on the genetic risk of obesity

T2 - The population architecture using genomics and epidemiology study

AU - Fesinmeyer, Megan D.

AU - North, Kari E.

AU - Lim, Unhee

AU - Bůžková, Petra

AU - Crawford, Dana C.

AU - Haessler, Jeffrey

AU - Gross, Myron D.

AU - Fowke, Jay H.

AU - Goodloe, Robert

AU - Love, Shelley Ann

AU - Graff, Misa

AU - Carlson, Christopher S.

AU - Kuller, Lewis H.

AU - Matise, Tara C.

AU - Hong, Ching Ping

AU - Henderson, Brian E.

AU - Allen, Melissa

AU - Rohde, Rebecca R.

AU - Mayo, Ping

AU - Schnetz-Boutaud, Nathalie

AU - Monroe, Kristine R.

AU - Ritchie, Marylyn D.

AU - Prentice, Ross L.

AU - Kolonel, Lawrence N.

AU - Manson, Jo Ann E.

AU - Pankow, James

AU - Hindorff, Lucia A.

AU - Franceschini, Nora

AU - Wilkens, Lynne R.

AU - Haiman, Christopher A.

AU - Le Marchand, Loic

AU - Peters, Ulrike

PY - 2013/1/11

Y1 - 2013/1/11

N2 - Background: Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored.Methods: As part of the 'Population Architecture using Genomics and Epidemiology (PAGE)' Consortium, we investigated interaction between genetic risk factors associated with BMI and smoking for 10 single nucleotide polymorphisms (SNPs) previously identified in genome-wide association studies. We included 6 studies with a total of 56,466 subjects (16,750 African Americans (AA) and 39,716 European Americans (EA)). We assessed effect modification by testing an interaction term for each SNP and smoking (current vs. former/never) in the linear regression and by stratified analyses.Results: We did not observe strong evidence for interactions and only observed two interactions with p-values <0.1: for rs6548238/TMEM18, the risk allele (C) was associated with BMI only among AA females who were former/never smokers (β = 0.018, p = 0.002), vs. current smokers (β = 0.001, p = 0.95, pinteraction = 0.10). For rs9939609/FTO, the A allele was more strongly associated with BMI among current smoker EA females (β = 0.017, p = 3.5x10-5), vs. former/never smokers (β = 0.006, p = 0.05, pinteraction = 0.08).Conclusions: These analyses provide limited evidence that smoking status may modify genetic effects of previously identified genetic risk factors for BMI. Larger studies are needed to follow up our results.Clinical Trial Registration: NCT00000611.

AB - Background: Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored.Methods: As part of the 'Population Architecture using Genomics and Epidemiology (PAGE)' Consortium, we investigated interaction between genetic risk factors associated with BMI and smoking for 10 single nucleotide polymorphisms (SNPs) previously identified in genome-wide association studies. We included 6 studies with a total of 56,466 subjects (16,750 African Americans (AA) and 39,716 European Americans (EA)). We assessed effect modification by testing an interaction term for each SNP and smoking (current vs. former/never) in the linear regression and by stratified analyses.Results: We did not observe strong evidence for interactions and only observed two interactions with p-values <0.1: for rs6548238/TMEM18, the risk allele (C) was associated with BMI only among AA females who were former/never smokers (β = 0.018, p = 0.002), vs. current smokers (β = 0.001, p = 0.95, pinteraction = 0.10). For rs9939609/FTO, the A allele was more strongly associated with BMI among current smoker EA females (β = 0.017, p = 3.5x10-5), vs. former/never smokers (β = 0.006, p = 0.05, pinteraction = 0.08).Conclusions: These analyses provide limited evidence that smoking status may modify genetic effects of previously identified genetic risk factors for BMI. Larger studies are needed to follow up our results.Clinical Trial Registration: NCT00000611.

UR - http://www.scopus.com/inward/record.url?scp=84872156946&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872156946&partnerID=8YFLogxK

U2 - 10.1186/1471-2350-14-6

DO - 10.1186/1471-2350-14-6

M3 - Article

C2 - 23311614

AN - SCOPUS:84872156946

VL - 14

JO - BMC Medical Genetics

JF - BMC Medical Genetics

SN - 1471-2350

IS - 1

M1 - 6

ER -