Effects of topical timolol (0.5%) and betaxolol (0.5%) on corneal sensitivity

S. S. Weissman, Penny Asbell

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

There are conflicting reports on the propensity of topical 1B blockers to produce corneal anaesthesia. We measured corneal sensitivity thresholds quantitatively for 10 minutes following the administration of one drop of topical timolol maleate (0.5%), betaxolol hydrochloride (0.5%), or saline in 30 eyes of 18 normal subjects in a randomised, doublemasked study. Most subjects had insignificant changes in corneal sensitivity thresholds. We identified, however, a subgroup of four subjects (five eyes) that had a marked and prolonged increase of corneal sensitivity threshold (corneal anaesthesia) after timolol (three eyes) and betaxolol (two eyes). The group mean age of these 'responders' (49.0 years) was significantly greater (p<0005) than that of the non-responders (35.0). We recommend periodic measurements of corneal sensitivity in older patients receiving topical timolol or betaxolol, especially when given in higher concentrations, to identify responders, who may be at risk of developing keratitis.

Original languageEnglish (US)
Pages (from-to)409-412
Number of pages4
JournalBritish Journal of Ophthalmology
Volume74
Issue number7
DOIs
StatePublished - Jan 1 1990

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Betaxolol
Timolol
Anesthesia
Keratitis
Age Groups

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Effects of topical timolol (0.5%) and betaxolol (0.5%) on corneal sensitivity. / Weissman, S. S.; Asbell, Penny.

In: British Journal of Ophthalmology, Vol. 74, No. 7, 01.01.1990, p. 409-412.

Research output: Contribution to journalArticle

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