Effects of unilateral motor cortex lesion on ipsilesional hand's reach and grasp performance in monkeys

Relationship with recovery in the contralesional hand

Mélanie Kaeser, Alexander F. Wyss, Shahid Bashir, Adjia Hamadjida, Yu Liu, Jocelyne Bloch, Jean François Brunet, Abderaouf Belhaj-Saif, Eric M. Rouiller

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Manual dexterity, a prerogative of primates, is under the control of the corticospinal (CS) tract. Because 90-95% of CS axons decussate, it is assumed that this control is exerted essentially on the contralateral hand. Consistently, unilateral lesion of the hand representation in the motor cortex is followed by a complete loss of dexterity of the contralesional hand. During the months following lesion, spontaneous recovery of manual dexterity takes place to a highly variable extent across subjects, although largely incomplete. In the present study, we tested the hypothesis that after a significant postlesion period, manual performance in the ipsilesional hand is correlated with the extent of functional recovery in the contralesional hand. To this aim, ten adult macaque monkeys were subjected to permanent unilateral motor cortex lesion. Monkeys' manual performance was assessed for each hand during several months postlesion, using our standard behavioral test (modified Brinkman board task) that provides a quantitative measure of reach and grasp ability. The ipsilesional hand's performance was found to be significantly enhanced over the long term (100-300 days postlesion) in six of ten monkeys, with the six exhibiting the best, though incomplete, recovery of the contralesional hand. There was a statistically significant correlation (r = 0.932; P < 0.001) between performance in the ipsilesional hand after significant postlesion period and the extent of recovery of the contralesional hand. This observation is interpreted in terms of different possible mechanisms of recovery, dependent on the recruitment of motor areas in the lesioned and/or intact hemispheres.

Original languageEnglish (US)
Pages (from-to)1630-1645
Number of pages16
JournalJournal of neurophysiology
Volume103
Issue number3
DOIs
StatePublished - Mar 1 2010

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Motor Cortex
Hand Strength
Haplorhini
Hand
Pyramidal Tracts
Aptitude
Macaca
Primates
Axons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Cite this

Effects of unilateral motor cortex lesion on ipsilesional hand's reach and grasp performance in monkeys : Relationship with recovery in the contralesional hand. / Kaeser, Mélanie; Wyss, Alexander F.; Bashir, Shahid; Hamadjida, Adjia; Liu, Yu; Bloch, Jocelyne; Brunet, Jean François; Belhaj-Saif, Abderaouf; Rouiller, Eric M.

In: Journal of neurophysiology, Vol. 103, No. 3, 01.03.2010, p. 1630-1645.

Research output: Contribution to journalArticle

Kaeser, Mélanie ; Wyss, Alexander F. ; Bashir, Shahid ; Hamadjida, Adjia ; Liu, Yu ; Bloch, Jocelyne ; Brunet, Jean François ; Belhaj-Saif, Abderaouf ; Rouiller, Eric M. / Effects of unilateral motor cortex lesion on ipsilesional hand's reach and grasp performance in monkeys : Relationship with recovery in the contralesional hand. In: Journal of neurophysiology. 2010 ; Vol. 103, No. 3. pp. 1630-1645.
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