Efficacy and Tolerability of the New Antiepileptic Drugs, II: Treatment of Refractory Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society

Jacqueline A. French, Andres M. Kanner, Jocelyn Bautista, Bassel Abou-Khalil, Thomas Browne, Cynthia L. Harden, William H. Theodore, Carl Bazil, John Stern, Steven C. Schachter, Donna Bergen, Deborah Hirtz, Georgia D. Montouris, Mark Nespeca, Barry Gidal, William J. Marks, William R. Turk, James H. Fischer, Blaise Bourgeois, Andrew WilnerR. Edward Faught, Rajesh C. Sachdeo, Ahmad Beydoun, Tracy A. Glauser

Research output: Contribution to journalReview article

101 Citations (Scopus)

Abstract

Purpose: To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) [gabapentin (GBP), lamotrigine (LTG), topiramate (TPM), tiagabine (TGB), oxcarbazepine (OXC), levetiracetam (LEV), and zonisamide (ZNS)] in the treatment of children and adults with refractory partial and generalized epilepsies. Methods: A 23-member committee, including general neurologists, pediatric neurologists, epileptologists, and doctors in pharmacy, evaluated the available evidence based on a structured literature review including MEDLINE, Current Contents, and Cochrane Library for relevant articles from 1987 to March 2003. Results: All of the new AEDs were found to be appropriate for adjunctive treatment of refractory partial seizures in adults. GBP can be effective for the treatment of mixed seizure disorders, and GBP, LTG, OXC, and TPM for the treatment of refractory partial seizures in children. Limited evidence suggests that LTG and TPM also are effective for adjunctive treatment of idiopathic generalized epilepsy in adults and children, as well as treatment of the Lennox-Gastaut syndrome. Conclusions: The choice of AED depends on seizure and/or syndrome type, patient age, concomitant medications, and AED tolerability, safety, and efficacy. The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with refractory epilepsy and identify those seizure types and syndromes for which more evidence is necessary.

Original languageEnglish (US)
Pages (from-to)410-423
Number of pages14
JournalEpilepsia
Volume45
Issue number5
DOIs
StatePublished - May 1 2004

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Anticonvulsants
Epilepsy
Seizures
zonisamide
etiracetam
Therapeutics
Committee Membership
Safety
Generalized Epilepsy
Partial Epilepsy
Prescription Drugs
MEDLINE
Libraries
Guidelines
Pediatrics
topiramate
gabapentin
lamotrigine
oxcarbazepine
Neurologists

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Efficacy and Tolerability of the New Antiepileptic Drugs, II : Treatment of Refractory Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. / French, Jacqueline A.; Kanner, Andres M.; Bautista, Jocelyn; Abou-Khalil, Bassel; Browne, Thomas; Harden, Cynthia L.; Theodore, William H.; Bazil, Carl; Stern, John; Schachter, Steven C.; Bergen, Donna; Hirtz, Deborah; Montouris, Georgia D.; Nespeca, Mark; Gidal, Barry; Marks, William J.; Turk, William R.; Fischer, James H.; Bourgeois, Blaise; Wilner, Andrew; Faught, R. Edward; Sachdeo, Rajesh C.; Beydoun, Ahmad; Glauser, Tracy A.

In: Epilepsia, Vol. 45, No. 5, 01.05.2004, p. 410-423.

Research output: Contribution to journalReview article

French, JA, Kanner, AM, Bautista, J, Abou-Khalil, B, Browne, T, Harden, CL, Theodore, WH, Bazil, C, Stern, J, Schachter, SC, Bergen, D, Hirtz, D, Montouris, GD, Nespeca, M, Gidal, B, Marks, WJ, Turk, WR, Fischer, JH, Bourgeois, B, Wilner, A, Faught, RE, Sachdeo, RC, Beydoun, A & Glauser, TA 2004, 'Efficacy and Tolerability of the New Antiepileptic Drugs, II: Treatment of Refractory Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society', Epilepsia, vol. 45, no. 5, pp. 410-423. https://doi.org/10.1111/j.0013-9580.2004.06304.x
French, Jacqueline A. ; Kanner, Andres M. ; Bautista, Jocelyn ; Abou-Khalil, Bassel ; Browne, Thomas ; Harden, Cynthia L. ; Theodore, William H. ; Bazil, Carl ; Stern, John ; Schachter, Steven C. ; Bergen, Donna ; Hirtz, Deborah ; Montouris, Georgia D. ; Nespeca, Mark ; Gidal, Barry ; Marks, William J. ; Turk, William R. ; Fischer, James H. ; Bourgeois, Blaise ; Wilner, Andrew ; Faught, R. Edward ; Sachdeo, Rajesh C. ; Beydoun, Ahmad ; Glauser, Tracy A. / Efficacy and Tolerability of the New Antiepileptic Drugs, II : Treatment of Refractory Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society. In: Epilepsia. 2004 ; Vol. 45, No. 5. pp. 410-423.
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abstract = "Purpose: To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs (AEDs) [gabapentin (GBP), lamotrigine (LTG), topiramate (TPM), tiagabine (TGB), oxcarbazepine (OXC), levetiracetam (LEV), and zonisamide (ZNS)] in the treatment of children and adults with refractory partial and generalized epilepsies. Methods: A 23-member committee, including general neurologists, pediatric neurologists, epileptologists, and doctors in pharmacy, evaluated the available evidence based on a structured literature review including MEDLINE, Current Contents, and Cochrane Library for relevant articles from 1987 to March 2003. Results: All of the new AEDs were found to be appropriate for adjunctive treatment of refractory partial seizures in adults. GBP can be effective for the treatment of mixed seizure disorders, and GBP, LTG, OXC, and TPM for the treatment of refractory partial seizures in children. Limited evidence suggests that LTG and TPM also are effective for adjunctive treatment of idiopathic generalized epilepsy in adults and children, as well as treatment of the Lennox-Gastaut syndrome. Conclusions: The choice of AED depends on seizure and/or syndrome type, patient age, concomitant medications, and AED tolerability, safety, and efficacy. The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with refractory epilepsy and identify those seizure types and syndromes for which more evidence is necessary.",
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T2 - Treatment of Refractory Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society

AU - French, Jacqueline A.

AU - Kanner, Andres M.

AU - Bautista, Jocelyn

AU - Abou-Khalil, Bassel

AU - Browne, Thomas

AU - Harden, Cynthia L.

AU - Theodore, William H.

AU - Bazil, Carl

AU - Stern, John

AU - Schachter, Steven C.

AU - Bergen, Donna

AU - Hirtz, Deborah

AU - Montouris, Georgia D.

AU - Nespeca, Mark

AU - Gidal, Barry

AU - Marks, William J.

AU - Turk, William R.

AU - Fischer, James H.

AU - Bourgeois, Blaise

AU - Wilner, Andrew

AU - Faught, R. Edward

AU - Sachdeo, Rajesh C.

AU - Beydoun, Ahmad

AU - Glauser, Tracy A.

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