Efficient synthesis of tertiary amines from secondary amines

Michio Kurosu, Sevendu Sekhar Dey, Dean C. Crick

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Reliable N-alkylations of secondary amines have been developed. By using DIAD and TPP (or PS-TPP) a variety of secondary amines can be converted to the corresponding tertiary amines in good to excellent yields with diverse alkylhalides; no formation of quaternary amine salts are observed. These protocols are amenable to combinatorial chemistry libraries, and are also useful for the syntheses of secondary amines by an acid lysis of the cleavable tertiary amino resins.

Original languageEnglish (US)
Pages (from-to)4871-4875
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number28
DOIs
StatePublished - Jul 12 2006

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Amines
Alkylation
Libraries
Salts
Acids

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Efficient synthesis of tertiary amines from secondary amines. / Kurosu, Michio; Dey, Sevendu Sekhar; Crick, Dean C.

In: Tetrahedron Letters, Vol. 47, No. 28, 12.07.2006, p. 4871-4875.

Research output: Contribution to journalArticle

Kurosu, Michio ; Dey, Sevendu Sekhar ; Crick, Dean C. / Efficient synthesis of tertiary amines from secondary amines. In: Tetrahedron Letters. 2006 ; Vol. 47, No. 28. pp. 4871-4875.
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