EGF content in the gastrointestinal tract of rats

Effect of age and fasting/feeding

R. P. Schaudies, J. Grimes, D. Davis, Radhakrishna Rao, O. Koldovsky

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Immunoreactive rat epidermal growth factor (EGF) was measured in the pancreas and in the mucosa and lumen of the stomach, duodenum, jejunum, midjejunum, ileum, and colon of fed or fasted 5- and 12-day-old suckling, and 3- to 4-month-old adult male rats using a homologous radioimmunoassay. The EGF levels in the pancreas in sucklings were lower than in adults and were unaffected by fasting. Both gastrointestinal mucosal and luminal EGF levels were higher in suckling rats than in adults. Fasting caused a significant decrease in gastrointestinal levels of EGF in the suckling rats but resulted in minimal changes in the adults. Our results show that the content of EGF in gastrointestinal tract is dependent on both age and dietary status. Together with the fact that milk contains a large amount of EGF (O. Koldovsky and W. Thornburg, J. Pediatr. Gastro. Nutr. 6: 172-196, 1987) and that labeled EGF is absorbed to a considerable extent by the gastrointestinal tract of suckling rats (P.A. Gonella et al., J. Clin. Invest. 80: 22-32, 1987: W. Thornburg et al., Am. J. Physiol. 246: G80-G85, 1984), our present study implicates milk as an important source of EGF in the suckling period.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume256
Issue number5
StatePublished - 1989
Externally publishedYes

Fingerprint

Epidermal Growth Factor
Gastrointestinal Tract
Fasting
Pancreas
Milk
Jejunum
Ileum
Duodenum
Radioimmunoassay
Stomach
Colon
Mucous Membrane

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

EGF content in the gastrointestinal tract of rats : Effect of age and fasting/feeding. / Schaudies, R. P.; Grimes, J.; Davis, D.; Rao, Radhakrishna; Koldovsky, O.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 256, No. 5, 1989.

Research output: Contribution to journalArticle

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