Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus

R. P. White, Charles Leffler, H. S. Bada

Research output: Contribution to journalArticle

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Abstract

The cerebrospinal fluid (CSF) of 11 premature infants suffering from posthemorrhagic hydrocephalus was examined by radioimmunoassay for prostaglandin (PG) E2, PGF(2α), PGD2, 6-keto PGF(1α), thromboxane B2 (TxB2) and peptidoleukotrienes (LTC4/LTD4). The Lts were detected in the CSF of more of these patients (70%) than any of the other eicosanoids, and usually in the highest concentration. Among the 11 posthemorrhagic patients CSF eicosanoid levels were highest when determined soon after injury. Moreover, the variety of eicosanoids present, as well as concentrations, in these infants decreased with time. The types of eicosanoids most evident in the CSF of patients who required shunting were TxB2 and LTs, being present together in 5 of 6 (83%) of these infants. In contrast, 1 of 5 (20%) of the patients who did not require this neurosurgical intervention contained both TxB2 and LTs, the remaining having only one or neither eicosanoid. The highest average concentration for each eicosanoid studied was (pg/ml): PGE2, 628; PGF(2α), 985, 1410; 6-keto PGF(1α), 544, TxB2, 486 and LTs, 1229. This study is the first to demonstrate that the CSF of preterm infants may contain a wide variety of eicosanoids and indicates that these lipids are a manifestation of neurological assault.

Original languageEnglish (US)
Pages (from-to)230-235
Number of pages6
JournalAmerican Journal of the Medical Sciences
Volume299
Issue number4
DOIs
StatePublished - Jan 1 1990

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Eicosanoids
Hydrocephalus
Premature Infants
Cerebrospinal Fluid
Thromboxane B2
Prostaglandins F
Dinoprostone
Leukotriene D4
Prostaglandin D2
Leukotriene C4
Neurologic Manifestations
Radioimmunoassay
Lipids
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Eicosanoid levels in CSF of premature infants with posthemorrhagic hydrocephalus. / White, R. P.; Leffler, Charles; Bada, H. S.

In: American Journal of the Medical Sciences, Vol. 299, No. 4, 01.01.1990, p. 230-235.

Research output: Contribution to journalArticle

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