Electrocardiographic, biochemical, and morphologic abnormalities in dystrophic hamsters with cardiomyopathy

Syamal Bhattacharya, Alice J. Crawford, James W. Pate

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Electrocardiographic (EKG) changes were investigated in 7‐month‐old dystrophic hamsters (DH) with cardiomyopathy and were correlated with biochemical and histologic aberrations. Abnormally tall R‐I and R‐aVL amplitudes, deep S‐III and S‐aVR waves, and elongated PR‐I, QT‐I, and QRS‐I intervals (all at P <0.0001) were noted in DH compared with normal hamsters. These EKG changes are similar to those seen in Duchenne muscular dystrophy (DMD) and support cardiac hypertrophy (P < 0.001) in DH. Excessive intracellular calcium accumulation in the heart (P < 0.0001), diaphragm (P < 0.001), and rectus femoris (P < 0.05), and elevated plasma creatine kinase concentrations (P < 0.001) were also noted in DH. Histopathology in the cardiac and skeletal muscles of DH included fatty infiltration, centronucleation, and sporadic necrosis with calcium deposition. Observed EKG abnormalities, biochemical alterations, and histological aberrations in the cardiac and skeletal muscles of DH are strikingly similar to those reported in DMD and thus substantiate the relevance of DH as a suitable model for the study of muscular dystrophy and cardiac hypertrophy.

Original languageEnglish (US)
Pages (from-to)168-176
Number of pages9
JournalMuscle & Nerve
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1987

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Cardiomyopathies
Cricetinae
Diaphragm
Electrocardiography
Duchenne Muscular Dystrophy
Cardiomegaly
Myocardium
Skeletal Muscle
Calcium
Muscular Dystrophies
Quadriceps Muscle
Creatine Kinase
Necrosis

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Electrocardiographic, biochemical, and morphologic abnormalities in dystrophic hamsters with cardiomyopathy. / Bhattacharya, Syamal; Crawford, Alice J.; Pate, James W.

In: Muscle & Nerve, Vol. 10, No. 2, 01.01.1987, p. 168-176.

Research output: Contribution to journalArticle

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