Electrocardiographic changes after intravenous administration of magnesium in rabbits

Makoto Nonaka, Leo E. Ondrovic, Steven M. Schultz, Peter Mckeown

Research output: Contribution to journalArticle

Abstract

Magnesium (Mg+2) therapy has a beneficial effect in various cardiovascular diseases. However, overdosage of Mg+2 can be fatal. This study was undertaken to determine the amount of Mg+2 that can be safely administered intravenously to rabbits. Twenty New Zealand White rabbits were allotted to three groups. One hundred milliliters of 0.9% NaCl/kg was infused in group-1 rabbits (n = 10) used as a control group. Rabbits in group 2 (n = 6) and group 3 (n = 4) received MgCl2 (2.5 mmol and 5.0 mmol/kg respectively) in 0.9% NaCI (100 ml/kg). The infusion was delivered intravenously for 30 min (group 2, 8 mg/kg per min; group 3, 16 mg/kg per min). The electrocardiogram was monitored throughout the infusion; the P-R interval, QRS duration, and QTc interval of group-2 and group-3 rabbits were prolonged at dosages of 0.8 mmol/kg, 1.7 mmol/kg, and 5.0 mmol/kg of MgCl2 respectively, compared with readings in group-1 rabbits. We hypothesized that the mean + 2 standard deviations of the pre-operative baseline values was the safe limit. On the basis of this hypothesis, the safe limit of the P-R interval is 95.3 milliseconds, which corresponds to 0.6 mmol/kg of infused Mg+2; the QRS duration is 44.4 milliseconds, which corresponds to 1.0 mmol of Mg+2/kg; and the QTc interval is 350.0 milliseconds, which corresponds to 3.6 mmol of Mg+2/kg. These results will provide guidance for avoiding cardiac side effects when researchers investigate the effects of Mg+2 in rabbits.

Original languageEnglish (US)
Pages (from-to)434-437
Number of pages4
JournalLaboratory Animal Science
Volume46
Issue number4
StatePublished - Dec 1 1996

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Magnesium Chloride
intravenous injection
Intravenous Administration
Magnesium
magnesium
rabbits
Rabbits
Electrocardiography
duration
New Zealand White rabbit
electrocardiography
normal values
cardiovascular diseases
researchers
adverse effects
Reading
Cardiovascular Diseases
Research Personnel
therapeutics
Control Groups

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Electrocardiographic changes after intravenous administration of magnesium in rabbits. / Nonaka, Makoto; Ondrovic, Leo E.; Schultz, Steven M.; Mckeown, Peter.

In: Laboratory Animal Science, Vol. 46, No. 4, 01.12.1996, p. 434-437.

Research output: Contribution to journalArticle

Nonaka, Makoto ; Ondrovic, Leo E. ; Schultz, Steven M. ; Mckeown, Peter. / Electrocardiographic changes after intravenous administration of magnesium in rabbits. In: Laboratory Animal Science. 1996 ; Vol. 46, No. 4. pp. 434-437.
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