Electrocardiographic characterization of Rhesus monkey model of ischemic myocardial infarction induced by left anterior descending artery ligation

Pingliang Yang, Pengfei Han, Jianglong Hou, Lizhi Zhang, Haibo Song, Yuping Xie, Yonglin Chen, Huiqi Xie, Fabao Gao, Yujian Kang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Myocardial infarction is a leading cause for morbidity and mortality in the modern society. Rhesus monkeys are excellent animal models for experimental and translational studies of cardiovascular diseases in humans. However, some detailed characterizations of cardiovascular disease, such as myocardial infarction, in Rhesus monkeys have not been available. The present study was undertaken to examine the progressive electrocardiographic changes in Rhesus monkeys after left anterior descending (LAD) artery ligation. Male Rhesus monkeys, aged 2-3 years and weighed 4.5-6.0 kg, were subjected to LAD ligation along with sham-operated controls. At 1 week, 1 month, and 6 months after the LAD ligation, ECG recording was performed to detect the progressive changes in ECG. In addition, cardiac magnetic resonance imaging (MRI) and echocardiography were applied to detect the myocardial infarction induced by LAD ligation, and histopathological examination was performed at the end of the experiment to measure the morphological changes. The results showed that QRS and ST-T changed significantly within 1 month after LAD ligation, but recovered to normal at the end of the experiment. The most significant change was a progressive QTc prolongation, which occurred corresponding to the development of myocardial infarction. Both cardiac MRI and echocardiography detected the myocardial infarction that was confirmed by the histopathological examination. This detailed characterization of ECG changes along with the development of myocardial infarction induced by LAD ligation thus demonstrated that the Rhesus monkey model of ischemic myocardial infarction would be an excellent surrogate for human myocardial infarction. This model would also provide an excellent tool for drug discovery and development for cardiac disease.

Original languageEnglish (US)
Pages (from-to)365-372
Number of pages8
JournalCardiovascular Toxicology
Volume11
Issue number4
DOIs
StatePublished - Dec 1 2011

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Macaca mulatta
Electrocardiography
Ligation
Echocardiography
Arteries
Myocardial Infarction
Magnetic resonance
Imaging techniques
Animals
Experiments
Cardiovascular Diseases
Magnetic Resonance Imaging
Drug Discovery
Heart Diseases
Animal Models
Morbidity
Mortality

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

Cite this

Electrocardiographic characterization of Rhesus monkey model of ischemic myocardial infarction induced by left anterior descending artery ligation. / Yang, Pingliang; Han, Pengfei; Hou, Jianglong; Zhang, Lizhi; Song, Haibo; Xie, Yuping; Chen, Yonglin; Xie, Huiqi; Gao, Fabao; Kang, Yujian.

In: Cardiovascular Toxicology, Vol. 11, No. 4, 01.12.2011, p. 365-372.

Research output: Contribution to journalArticle

Yang, Pingliang ; Han, Pengfei ; Hou, Jianglong ; Zhang, Lizhi ; Song, Haibo ; Xie, Yuping ; Chen, Yonglin ; Xie, Huiqi ; Gao, Fabao ; Kang, Yujian. / Electrocardiographic characterization of Rhesus monkey model of ischemic myocardial infarction induced by left anterior descending artery ligation. In: Cardiovascular Toxicology. 2011 ; Vol. 11, No. 4. pp. 365-372.
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