Electrochemical quantification of 2,6-diisopropylphenol (propofol)

Jan Langmaier, Fernando Garay, Francine Kivlehan, Edward Chaum, Erno Lindner

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

2,6-Diisopropylphenol (propofol) is a potent anesthetic drug with fast onset of the anesthetic effect and short recovery time for the patients. Outside of the United States, propofol is widely used in performing target controlled infusion anesthesia. With the long term vision of an electrochemical sensor for in vivo monitoring and feedback controlled dosing of propofol in blood, different alternatives for the electrochemical quantification of propofol using diverse working electrodes and experimental conditions are presented in this contribution.When the electrochemical oxidation of propofol takes place on a glassy carbon working electrode, an electrochemically active film grows on the electrode surface. The reduction current of the film is proportional to the propofol concentration and the accumulation time. Based on these findings a stripping analytical method was developed for the detection of propofol in acidic solutions between 0 and 30 μM, with a detection limit of 5.5 ± 0.4 μM.By restricting the scanned potential window between 0.5. V and 1.0. V in cyclic voltammetric experiments, the formation of the electrochemically active polymer can be prevented. This allowed the development of a direct voltammetric method for assessing propofol in acidic solutions between 0 and 30 μM, with a 3.2 ± 0.1 μM (n= 3) detection limit.The stripping method has a better sensitivity but somewhat worse reproducibility because the electrode surface has to be renewed between each experiment. The direct method does not require the renewal of the electrode surface between measurements but has no adequate selectivity towards the common interfering compounds.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalAnalytica Chimica Acta
Volume704
Issue number1-2
DOIs
StatePublished - Oct 17 2011

Fingerprint

Propofol
electrode
anesthetic
Electrodes
Anesthetics
Limit of Detection
analytical method
drug
polymer
experiment
blood
Electrochemical sensors
sensor
oxidation
Electrochemical oxidation
Surface measurement
Glassy carbon
carbon
monitoring
Polymers

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

Cite this

Langmaier, J., Garay, F., Kivlehan, F., Chaum, E., & Lindner, E. (2011). Electrochemical quantification of 2,6-diisopropylphenol (propofol). Analytica Chimica Acta, 704(1-2), 63-67. https://doi.org/10.1016/j.aca.2011.08.003

Electrochemical quantification of 2,6-diisopropylphenol (propofol). / Langmaier, Jan; Garay, Fernando; Kivlehan, Francine; Chaum, Edward; Lindner, Erno.

In: Analytica Chimica Acta, Vol. 704, No. 1-2, 17.10.2011, p. 63-67.

Research output: Contribution to journalArticle

Langmaier, J, Garay, F, Kivlehan, F, Chaum, E & Lindner, E 2011, 'Electrochemical quantification of 2,6-diisopropylphenol (propofol)', Analytica Chimica Acta, vol. 704, no. 1-2, pp. 63-67. https://doi.org/10.1016/j.aca.2011.08.003
Langmaier J, Garay F, Kivlehan F, Chaum E, Lindner E. Electrochemical quantification of 2,6-diisopropylphenol (propofol). Analytica Chimica Acta. 2011 Oct 17;704(1-2):63-67. https://doi.org/10.1016/j.aca.2011.08.003
Langmaier, Jan ; Garay, Fernando ; Kivlehan, Francine ; Chaum, Edward ; Lindner, Erno. / Electrochemical quantification of 2,6-diisopropylphenol (propofol). In: Analytica Chimica Acta. 2011 ; Vol. 704, No. 1-2. pp. 63-67.
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