Electrophysiological and functional connectivity of the human supplementary motor area

Shalini Narayana, Angela R. Laird, Nitin Tandon, Crystal Franklin, Jack L. Lancaster, Peter T. Fox

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Neuro-imaging methods for detecting functional and structural inter-regional connectivity are in a rapid phase of development. While reports of regional connectivity patterns based on individual methods are becoming common, studies comparing the results of two or more connectivity-mapping methods remain rare. In this study, we applied transcranial magnetic stimulation during PET imaging (TMS/PET), a stimulation-based method, and meta-analytic connectivity modeling (MACM), a task-based method to map the connectivity patterns of the supplementary motor area (SMA). Further, we drew upon the behavioral domain meta-data of the BrainMap ® database to characterize the behavioral domain specificity of two maps. Both MACM and TMS/PET detected multi-synaptic connectivity patterns, with the MACM-detected connections being more extensive. Both MACM and TMS/PET detected connections belonging to multiple behavioral domains, including action, cognition and perception. Finally, we show that the two connectivity-mapping methods are complementary in that, the MACM informed on the functional nature of SMA connections, while TMS/PET identified brain areas electrophysiologically connected with the SMA. Thus, we demonstrate that integrating multimodal database and imaging techniques can derive comprehensive connectivity maps of brain areas.

Original languageEnglish (US)
Pages (from-to)250-265
Number of pages16
JournalNeuroImage
Volume62
Issue number1
DOIs
StatePublished - Aug 1 2012

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Motor Cortex
Transcranial Magnetic Stimulation
Multimodal Imaging
Databases
Neuroimaging
Cognition
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Electrophysiological and functional connectivity of the human supplementary motor area. / Narayana, Shalini; Laird, Angela R.; Tandon, Nitin; Franklin, Crystal; Lancaster, Jack L.; Fox, Peter T.

In: NeuroImage, Vol. 62, No. 1, 01.08.2012, p. 250-265.

Research output: Contribution to journalArticle

Narayana, Shalini ; Laird, Angela R. ; Tandon, Nitin ; Franklin, Crystal ; Lancaster, Jack L. ; Fox, Peter T. / Electrophysiological and functional connectivity of the human supplementary motor area. In: NeuroImage. 2012 ; Vol. 62, No. 1. pp. 250-265.
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