Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM2.5) in rats with acute myocardial infarction

Yujian Kang, Yan Li, Zhanxiang Zhou, Andrew M. Roberts, Lu Cai, Steven R. Myers, Lipeng Wang, Dale A. Schuschke

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Epidemiological studies have defined a significant positive association of acute exposure to ambient concentrations of particulate matter (PM) with increased daily mortality and hospital admission for cardiovascular diseases. Experimental studies have shown that animals with pre-existing cardiovascular diseases are more susceptible to the cardiac effect of PM exposure. The present study was undertaken to investigate possible involvement of upregulation of the endothelin system in PM exposure-induced cardiotoxicity in rats with acute myocardial infarction (MI). Adult male Sprague-Dawley rats were subjected to occlusion of the left coronary artery and displayed myocardial infarction 12 h after the surgery. The heart rate significantly decreased and premature ventricular complexes of the electrocardiogram occurred in the myocardial infarct animals. Exposure to PM2.5 via intratracheal instillation with 2.0 mg in 0.3 mL normal saline significantly worsened the ventricular arrhythmia along with a further decrease in heart rate. The same PM exposure only caused slight cardiac changes in the sham-operated animals. Serum total endothelin concentrations were significantly elevated in both myocardial infarct rats and sham-operated controls in response to PM exposure. However, increased numbers of the endothelin receptor type A on the cardiomyocytes were observed only in the infarct myocardium. This study thus suggests that upregulation of the endothelin system in rats with MI is likely involved in the PM exposure-induced cardiotoxicity.

Original languageEnglish (US)
Pages (from-to)253-261
Number of pages9
JournalCardiovascular Toxicology
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

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Particulate Matter
Endothelins
Rats
Myocardial Infarction
Serum
Animals
Cardiovascular Diseases
Up-Regulation
Heart Rate
Endothelin A Receptors
Preexisting Condition Coverage
Ventricular Premature Complexes
Hospital Mortality
Electrocardiography
Cardiac Myocytes
Surgery
Sprague Dawley Rats
Cardiotoxicity
Cardiac Arrhythmias
Epidemiologic Studies

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Toxicology
  • Cardiology and Cardiovascular Medicine

Cite this

Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM2.5) in rats with acute myocardial infarction. / Kang, Yujian; Li, Yan; Zhou, Zhanxiang; Roberts, Andrew M.; Cai, Lu; Myers, Steven R.; Wang, Lipeng; Schuschke, Dale A.

In: Cardiovascular Toxicology, Vol. 2, No. 4, 01.12.2002, p. 253-261.

Research output: Contribution to journalArticle

Kang, Yujian ; Li, Yan ; Zhou, Zhanxiang ; Roberts, Andrew M. ; Cai, Lu ; Myers, Steven R. ; Wang, Lipeng ; Schuschke, Dale A. / Elevation of serum endothelins and cardiotoxicity induced by particulate matter (PM2.5) in rats with acute myocardial infarction. In: Cardiovascular Toxicology. 2002 ; Vol. 2, No. 4. pp. 253-261.
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