Elucidation of Renal Scars in Children With Vesicoureteral Reflux Using Contrast-Enhanced Ultrasound

A Pilot Study

David Hains, Harris Cohen, M. Beth McCarville, Ellen E. Ellison, Amy Huffman, Stacey Glass, Aslam H. Qureshi, Keith R. Pierce, Ashlyn L. Cahill, Ashley Dixon, Noel Delos Santos

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction Vesicoureteral reflux is a common disorder in children but can result in kidney scarring following acute pyelonephritis. The gold standard diagnostic to detect renal scars in children is 99mTc-dimercaptosuccinic acid (DMSA) scintigraphy. DMSA has a number of limitations including radiation exposure, need for sedation, and radiotracer supply shortages. Contrast-enhanced ultrasound (CEUS) is a technique whereby biocompatible microspheres of inert gas are administered i.v. that reflect ultrasonography sound waves and do not involve radiation. Because the contrast agent is rapidly cleared, contrast images must be obtained within minutes of administration. CEUS has been used in a variety of organ systems, but its use in pediatric kidney diseases is limited. Methods In this study, we performed CEUS in 7 children with documented renal scars by radiographic imaging consistent with reflux nephropathy. Results In all subjects, CEUS detected all previously known radiologic abnormalities as well as detecting new areas of hypoenhancing renal parenchyma. None of the patients experienced any serious adverse events. Discussion This study represents the first report of using CEUS to characterize renal scars in children with reflux nephropathy. We conclude that CEUS is a highly sensitive, rapid, and cost-effective diagnostic imaging modality for detecting and monitoring renal scars in children with vesicoureteral reflux.

Original languageEnglish (US)
Pages (from-to)420-424
Number of pages5
JournalKidney International Reports
Volume2
Issue number3
DOIs
StatePublished - May 1 2017

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Cicatrix
Kidney
Vesico-Ureteral Reflux
Technetium Tc 99m Dimercaptosuccinic Acid
Succimer
Noble Gases
Pyelonephritis
Kidney Diseases
Diagnostic Imaging
Microspheres
Radionuclide Imaging
Contrast Media
Ultrasonography
Radiation
Pediatrics
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Elucidation of Renal Scars in Children With Vesicoureteral Reflux Using Contrast-Enhanced Ultrasound : A Pilot Study. / Hains, David; Cohen, Harris; McCarville, M. Beth; Ellison, Ellen E.; Huffman, Amy; Glass, Stacey; Qureshi, Aslam H.; Pierce, Keith R.; Cahill, Ashlyn L.; Dixon, Ashley; Santos, Noel Delos.

In: Kidney International Reports, Vol. 2, No. 3, 01.05.2017, p. 420-424.

Research output: Contribution to journalArticle

Hains, D, Cohen, H, McCarville, MB, Ellison, EE, Huffman, A, Glass, S, Qureshi, AH, Pierce, KR, Cahill, AL, Dixon, A & Santos, ND 2017, 'Elucidation of Renal Scars in Children With Vesicoureteral Reflux Using Contrast-Enhanced Ultrasound: A Pilot Study', Kidney International Reports, vol. 2, no. 3, pp. 420-424. https://doi.org/10.1016/j.ekir.2017.01.008
Hains, David ; Cohen, Harris ; McCarville, M. Beth ; Ellison, Ellen E. ; Huffman, Amy ; Glass, Stacey ; Qureshi, Aslam H. ; Pierce, Keith R. ; Cahill, Ashlyn L. ; Dixon, Ashley ; Santos, Noel Delos. / Elucidation of Renal Scars in Children With Vesicoureteral Reflux Using Contrast-Enhanced Ultrasound : A Pilot Study. In: Kidney International Reports. 2017 ; Vol. 2, No. 3. pp. 420-424.
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