Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The in vitro studies have demonstrated the ability of 12/15-LOX metabolites in the expression of various genes and production of cytokine related to inflammation and resolution of inflammation. The studies with the use of knockout and transgenic animals for 12/15-LOX have further shown its involvement in the pathogenesis of a variety of human diseases, including cardiovascular, renal, neurological and metabolic disorders. This review summarizes our current knowledge on the role of 12/15-LOX in inflammation and various human diseases.

Original languageEnglish (US)
Pages (from-to)28-45
Number of pages18
JournalProgress in Lipid Research
Volume73
DOIs
StatePublished - Jan 1 2019

Fingerprint

Pathology
Metabolites
Inflammation
Omega-6 Fatty Acids
Genetically Modified Animals
Omega-3 Fatty Acids
Nervous System Diseases
Unsaturated Fatty Acids
Animals
Cardiovascular Diseases
Fatty Acids
Genes
12-15-lipoxygenase
Cytokines
Kidney
Lipids
Gene Expression
Enzymes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology

Cite this

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies. / Singh, Nikhlesh; Gadiparthi, Rao.

In: Progress in Lipid Research, Vol. 73, 01.01.2019, p. 28-45.

Research output: Contribution to journalReview article

@article{e6fc739e1ef34323926de3c67df04f47,
title = "Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies",
abstract = "12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The in vitro studies have demonstrated the ability of 12/15-LOX metabolites in the expression of various genes and production of cytokine related to inflammation and resolution of inflammation. The studies with the use of knockout and transgenic animals for 12/15-LOX have further shown its involvement in the pathogenesis of a variety of human diseases, including cardiovascular, renal, neurological and metabolic disorders. This review summarizes our current knowledge on the role of 12/15-LOX in inflammation and various human diseases.",
author = "Nikhlesh Singh and Rao Gadiparthi",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.plipres.2018.11.001",
language = "English (US)",
volume = "73",
pages = "28--45",
journal = "Progress in Lipid Research",
issn = "0163-7827",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

AU - Singh, Nikhlesh

AU - Gadiparthi, Rao

PY - 2019/1/1

Y1 - 2019/1/1

N2 - 12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The in vitro studies have demonstrated the ability of 12/15-LOX metabolites in the expression of various genes and production of cytokine related to inflammation and resolution of inflammation. The studies with the use of knockout and transgenic animals for 12/15-LOX have further shown its involvement in the pathogenesis of a variety of human diseases, including cardiovascular, renal, neurological and metabolic disorders. This review summarizes our current knowledge on the role of 12/15-LOX in inflammation and various human diseases.

AB - 12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The in vitro studies have demonstrated the ability of 12/15-LOX metabolites in the expression of various genes and production of cytokine related to inflammation and resolution of inflammation. The studies with the use of knockout and transgenic animals for 12/15-LOX have further shown its involvement in the pathogenesis of a variety of human diseases, including cardiovascular, renal, neurological and metabolic disorders. This review summarizes our current knowledge on the role of 12/15-LOX in inflammation and various human diseases.

UR - http://www.scopus.com/inward/record.url?scp=85057341269&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057341269&partnerID=8YFLogxK

U2 - 10.1016/j.plipres.2018.11.001

DO - 10.1016/j.plipres.2018.11.001

M3 - Review article

VL - 73

SP - 28

EP - 45

JO - Progress in Lipid Research

JF - Progress in Lipid Research

SN - 0163-7827

ER -