Emerging targets in the long QT syndromes and Brugada syndrome

Jeffrey Towbin, Matteo Vatta, Zhiquing Wang, Neil E. Bowles, Hua Li

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Sudden cardiac death is a significant problem in the United States, with an incidence reported to be greater than 300,000 persons per year [1]. Interest in identifying the underlying cause of the death has been focused on cases of unexpected arrhythmogenic death, which is estimated to represent 5% of all sudden deaths. In cases in which no structural heart disease can be identified, the long QT syndrome and ventricular pre-excitation are most commonly considered as likely causes. Brugada syndrome (also known by some investigators as idiopathic ventricular fibrillation [IVF]) [2], is a disease associated with an electrocardiographic abnormality of right bundle branch block (RBBB) with ST-elevation in the right precordial leads (V1-V3). Recently it has been added to the list of possible causes of sudden death in otherwise healthy, young individuals. The purpose of this paper is to describe the current understanding of the molecular genetics of inherited diseases in which arrhythmias are prominent features, specifically long QT syndrome and Brugada syndrome.

Original languageEnglish (US)
Pages (from-to)423-437
Number of pages15
JournalExpert Opinion on Therapeutic Targets
Volume3
Issue number3
DOIs
StatePublished - Sep 1 1999
Externally publishedYes

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Brugada Syndrome
Long QT Syndrome
Sudden Death
Cause of Death
Inborn Genetic Diseases
Bundle-Branch Block
Sudden Cardiac Death
Cardiac Arrhythmias
Molecular Biology
Heart Diseases
Research Personnel
Incidence
Paroxysmal ventricular fibrillation

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Emerging targets in the long QT syndromes and Brugada syndrome. / Towbin, Jeffrey; Vatta, Matteo; Wang, Zhiquing; Bowles, Neil E.; Li, Hua.

In: Expert Opinion on Therapeutic Targets, Vol. 3, No. 3, 01.09.1999, p. 423-437.

Research output: Contribution to journalReview article

Towbin, Jeffrey ; Vatta, Matteo ; Wang, Zhiquing ; Bowles, Neil E. ; Li, Hua. / Emerging targets in the long QT syndromes and Brugada syndrome. In: Expert Opinion on Therapeutic Targets. 1999 ; Vol. 3, No. 3. pp. 423-437.
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