Endocrine therapy and related issues in hormone receptor-positive early breast cancer

a roundtable discussion by the breast cancer therapy expert group (BCTEG)

Jame Abraham, Humberto Caldera, Robert Coleman, Anthony Elias, Matthew P. Goetz, Muaiad Kittaneh, Elyse Lower, Reshma Mahtani, E. Terry Mamounas, Mark Pegram, Hope Rugo, Lee Schwartzberg, Tiffany Traina, Chuck Vogel

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Purpose: Management of breast cancer is a rapidly evolving field, and, although evidence-based guidelines are available for clinicians to provide direction on critical issues in patient care, clinicians often left to address these issues in the context of community practice situations with their patients. These include the patient’s comorbid conditions, actual versus perceived benefit of treatments, patient’s compliance as well as financial/reimbursement issues, and long-term tolerability of therapy. Methods: A meeting of global oncology experts was convened in January 2017 with the belief that there is a gap in clinical practice guidance on several fundamental issues in breast cancer care, particularly in the community setting, where oncologists may encounter multiple tumor types. The goal was to discuss some of the most important questions in this area and provide some guidance for practicing oncologists. Results: Topics addressed included risk of contralateral breast cancer recurrence in patients with estrogen receptor-positive early breast cancer who have undergone 5 years of adjuvant endocrine therapy, adverse events associated with endocrine therapy and their management, emergent data on adjuvant bisphosphonate therapy and its apparent benefit in reducing breast cancer recurrence, recent findings of extended adjuvant endocrine therapy trials, and the use of currently available genomic biomarker tests as a means of further informing treatment decisions. Conclusions: A summary of the discussion on these topics and several ‘expert opinion statements’ are provided herein in an effort to convey the collective insights of the panel as it relates to current standard practice.

Original languageEnglish (US)
JournalBreast Cancer Research and Treatment
Volume169
Issue number1
DOIs
StatePublished - May 1 2018

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Group Psychotherapy
Hormones
Breast Neoplasms
Therapeutics
Recurrence
Diphosphonates
Expert Testimony
Patient Compliance
Estrogen Receptors
Patient Care
Biomarkers
Guidelines
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Endocrine therapy and related issues in hormone receptor-positive early breast cancer : a roundtable discussion by the breast cancer therapy expert group (BCTEG). / Abraham, Jame; Caldera, Humberto; Coleman, Robert; Elias, Anthony; Goetz, Matthew P.; Kittaneh, Muaiad; Lower, Elyse; Mahtani, Reshma; Terry Mamounas, E.; Pegram, Mark; Rugo, Hope; Schwartzberg, Lee; Traina, Tiffany; Vogel, Chuck.

In: Breast Cancer Research and Treatment, Vol. 169, No. 1, 01.05.2018.

Research output: Contribution to journalReview article

Abraham, J, Caldera, H, Coleman, R, Elias, A, Goetz, MP, Kittaneh, M, Lower, E, Mahtani, R, Terry Mamounas, E, Pegram, M, Rugo, H, Schwartzberg, L, Traina, T & Vogel, C 2018, 'Endocrine therapy and related issues in hormone receptor-positive early breast cancer: a roundtable discussion by the breast cancer therapy expert group (BCTEG)', Breast Cancer Research and Treatment, vol. 169, no. 1. https://doi.org/10.1007/s10549-018-4662-9
Abraham, Jame ; Caldera, Humberto ; Coleman, Robert ; Elias, Anthony ; Goetz, Matthew P. ; Kittaneh, Muaiad ; Lower, Elyse ; Mahtani, Reshma ; Terry Mamounas, E. ; Pegram, Mark ; Rugo, Hope ; Schwartzberg, Lee ; Traina, Tiffany ; Vogel, Chuck. / Endocrine therapy and related issues in hormone receptor-positive early breast cancer : a roundtable discussion by the breast cancer therapy expert group (BCTEG). In: Breast Cancer Research and Treatment. 2018 ; Vol. 169, No. 1.
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