Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells

Abdallah Hayar, Matthew Ennis

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In rat olfactory bulb slices, external tufted (ET) cells spontaneously generate spike bursts. Although ET cell bursting is intrinsically generated, its strength and precise timing may be regulated by synaptic input. We tested this hypothesis by analyzing whether the burst properties are modulated by activation of ionotropic γ-aminobutyric acid (GABA) and glutamate receptors. Blocking GABAA receptors increased - whereas blocking ionotropic glutamate receptors decreased - the number of spikes/burst without changing the interburst frequency. The GABAA agonist (isoguvacine, 10 μM) completely inhibited bursting or reduced the number of spikes/burst, suggesting a shunting effect. These findings indicate that the properties of ET cell spontaneous bursting are differentially controlled by GABAergic and glutamatergic fast synaptic transmission. We suggest that ET cell excitatory and inhibitory inputs may be encoded as a change in the pattern of spike bursting in ET cells, which together with mitral/ tufted cells constitute the output circuit of the olfactory bulb.

Original languageEnglish (US)
Pages (from-to)1052-1056
Number of pages5
JournalJournal of neurophysiology
Volume98
Issue number2
DOIs
StatePublished - Aug 1 2007

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Olfactory Bulb
gamma-Aminobutyric Acid
Glutamic Acid
GABA-A Receptor Agonists
Aminobutyrates
Ionotropic Glutamate Receptors
GABA Receptors
Glutamate Receptors
GABA-A Receptors
Synaptic Transmission

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Cite this

Endogenous GABA and glutamate finely tune the bursting of olfactory bulb external tufted cells. / Hayar, Abdallah; Ennis, Matthew.

In: Journal of neurophysiology, Vol. 98, No. 2, 01.08.2007, p. 1052-1056.

Research output: Contribution to journalArticle

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