Endogenous opioid peptides

Do they mediate the acute antihypertensive action of clonidine in humans?

Ellis R. Levin, Burt Sharp, Michael A. Weber, Jan I.M. Drayer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The involvement of endogenous opioid peptides in the antihypertensive action of acutely administered Clonidine, a centrally acting adrenergic agonist, was studied in humans. Eight hypertensive subjects received Clonidine 0.2 mg orally, naloxone 8 mg i.v. followed by a 0.13 mg/min infusion, and both drugs together on separate days. Clonidine resulted in a significant decrease in mean blood pressure, which was not affected by concomitant treatment with naloxone. Naloxone alone or with Clonidine caused significant elevations in plasma aldosterone, not mediated by increased plasma renin activity. Plasma β-endorphin was not increased after Clonidine administration. In humans, the antihypertensive effects of acute Clonidine administration do not appear to be mediated by the release or action of endogenous opioids.

Original languageEnglish (US)
Pages (from-to)193-199
Number of pages7
JournalHormone Research in Paediatrics
Volume23
Issue number4
DOIs
StatePublished - Jan 1 1986

Fingerprint

Opioid Peptides
Clonidine
Antihypertensive Agents
Naloxone
Endorphins
Adrenergic Agonists
Aldosterone
Renin
Opioid Analgesics
Blood Pressure
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Endogenous opioid peptides : Do they mediate the acute antihypertensive action of clonidine in humans? / Levin, Ellis R.; Sharp, Burt; Weber, Michael A.; Drayer, Jan I.M.

In: Hormone Research in Paediatrics, Vol. 23, No. 4, 01.01.1986, p. 193-199.

Research output: Contribution to journalArticle

Levin, Ellis R. ; Sharp, Burt ; Weber, Michael A. ; Drayer, Jan I.M. / Endogenous opioid peptides : Do they mediate the acute antihypertensive action of clonidine in humans?. In: Hormone Research in Paediatrics. 1986 ; Vol. 23, No. 4. pp. 193-199.
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