Endoplasmic reticulum stress in diabetes

New insights of clinical relevance

Muthuswamy Balasubramanyam, Raji Rajesh Lenin, Finny Monickaraj

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

The endoplasmic reticulum (ER) is a cellular compartment responsible for multiple important cellular functions including the biosynthesis and folding of newly synthesized proteins destined for secretion, such as insulin. A myriad of pathological and physiological factors perturb ER function and cause dysregulation of ER homeostasis, leading to ER stress. Accumulating evidence suggests that ER stress plays a role in the pathogenesis of diabetes, contributing to pancreatic β-cell loss and insulin resistance. ER stress may also link obesity, inflammation and insulin resistance in type 2 diabetes. In this review, we address the transition from physiology to pathology, namely how and why the physiological UPR evolves to a proapoptotic ER stress response in diabetes and its complications. Special attention was given to elucidate how ER stress could explain some of the 'clinical paradoxes' such as secondary sulfonylurea failure, initial worsening of retinopathy during tight glycemic control, insulin resistance induced by protease inhibitors and other clinically relevant observations.

Original languageEnglish (US)
Pages (from-to)111-118
Number of pages8
JournalIndian Journal of Clinical Biochemistry
Volume25
Issue number2
DOIs
StatePublished - Apr 1 2010

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Endoplasmic Reticulum Stress
Medical problems
Insulin
Endoplasmic Reticulum
Insulin Resistance
Biosynthesis
Physiology
Pathology
Protease Inhibitors
Diabetes Complications
Type 2 Diabetes Mellitus
Homeostasis
Obesity
Inflammation
Proteins

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Endoplasmic reticulum stress in diabetes : New insights of clinical relevance. / Balasubramanyam, Muthuswamy; Rajesh Lenin, Raji; Monickaraj, Finny.

In: Indian Journal of Clinical Biochemistry, Vol. 25, No. 2, 01.04.2010, p. 111-118.

Research output: Contribution to journalReview article

Balasubramanyam, Muthuswamy ; Rajesh Lenin, Raji ; Monickaraj, Finny. / Endoplasmic reticulum stress in diabetes : New insights of clinical relevance. In: Indian Journal of Clinical Biochemistry. 2010 ; Vol. 25, No. 2. pp. 111-118.
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