Endothelial Damage in Monkeys After Radial Keratotomy Performed with a Diamond Blade

Tatsuo Yamaguchi, Penny Asbell, Michael Ostrick, Aran Safir, Grace E. Kissling, Herbert E. Kaufman

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Anterior radial keratotomy was performed with a diamond blade in ten rhesus monkey eyes. Results were compared with those of a previous study in which a metal blade was used. Histologic assessment showed endothelial degeneration, but fewer edematous endothelial cells, than in the previous study. Specular microscopy demonstrated statistically significant endothelial cell losses (7.99%), when preoperative and threemonth postoperative values were compared. Autoradiography showed little cell division in the endothelial cell layer. Cell loss seemed to be repaired mainly by the spreading of neighboring cells. Endothelial cell division is also limited in humans, and the cumulative loss of cells due to surgical trauma combined with continuous damage-related losses and later agerelated reductions in cell numbers could produce corneal decompensation in some patients years after radial keratotomy.

Original languageEnglish (US)
Pages (from-to)765-769
Number of pages5
JournalArchives of Ophthalmology
Volume102
Issue number5
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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Radial Keratotomy
Diamond
Haplorhini
Endothelial Cells
Cell Division
Macaca mulatta
Autoradiography
Microscopy
Cell Count
Metals
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Endothelial Damage in Monkeys After Radial Keratotomy Performed with a Diamond Blade. / Yamaguchi, Tatsuo; Asbell, Penny; Ostrick, Michael; Safir, Aran; Kissling, Grace E.; Kaufman, Herbert E.

In: Archives of Ophthalmology, Vol. 102, No. 5, 01.01.1984, p. 765-769.

Research output: Contribution to journalArticle

Yamaguchi, Tatsuo ; Asbell, Penny ; Ostrick, Michael ; Safir, Aran ; Kissling, Grace E. ; Kaufman, Herbert E. / Endothelial Damage in Monkeys After Radial Keratotomy Performed with a Diamond Blade. In: Archives of Ophthalmology. 1984 ; Vol. 102, No. 5. pp. 765-769.
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