Endothelial influences on cerebrovascular tone

Jon Andresen, Nadeem Shafi, Robert M. Bryan

Research output: Contribution to journalReview article

169 Citations (Scopus)

Abstract

The cerebrovascular endothelium exerts a profound influence on cerebral vessels and cerebral blood flow. This review summarizes current knowledge of various dilator and constrictor mechanisms intrinsic to the cerebrovascular endothelium. The endothelium contributes to the resting tone of cerebral arteries and arterioles by tonically releasing nitric oxide (NO ). Dilations can occur by stimulated release of NO , endothelium-derived hyperpolarization factor, or prostanoids. During pathological conditions, the dilator influence of the endothelium can turn to that of constriction by a variety of mechanisms, including decreased NO bioavailability and release of endothelin-1. The endothelium may participate in neurovascular coupling by conducting local dilations to upstream arteries. Further study of the cerebrovascular endothelium is critical for understanding the pathogenesis of a number of pathological conditions, including stroke, traumatic brain injury, and subarachnoid hemorrhage.

Original languageEnglish (US)
Pages (from-to)318-327
Number of pages10
JournalJournal of Applied Physiology
Volume100
Issue number1
DOIs
StatePublished - Jan 1 2006

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Endothelium
Nitric Oxide
Traumatic Brain Hemorrhage
Dilatation
Cerebrovascular Circulation
Traumatic Subarachnoid Hemorrhage
Cerebral Arteries
Arterioles
Endothelin-1
Constriction
Biological Availability
Prostaglandins
Arteries
Stroke

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Endothelial influences on cerebrovascular tone. / Andresen, Jon; Shafi, Nadeem; Bryan, Robert M.

In: Journal of Applied Physiology, Vol. 100, No. 1, 01.01.2006, p. 318-327.

Research output: Contribution to journalReview article

Andresen, Jon ; Shafi, Nadeem ; Bryan, Robert M. / Endothelial influences on cerebrovascular tone. In: Journal of Applied Physiology. 2006 ; Vol. 100, No. 1. pp. 318-327.
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