Endothelin -1 levels in hypotensive trauma patients

Brian Daley, Blaine Enderson, Karen S. Hunter, Edgar Cruz

Research output: Contribution to journalArticle

Abstract

Objective: Measure the endothelial-released mediator of vasoconstriction, Endothelin-1 (Endo) in trauma patients with low blood pressures (BP in mm Hg). Methods: Over three months, 15 patients with initial BP < 90 had serum sampled on admission (Endo 1), and days 2 and 7 (Endo 2 and 3) after resuscitation. Endo levels were assayed by radioimmunoassay (Pennisula Labs, Belmont, CA). Results: Mean age was 55 years (25-84); there were 9 men and 6 women. BP pH BD Lact Vol RBC Endo Endo Endo 3 1 2 mean 75 7.34 4.2 4.0 12,159 5.9 24.7 17.1 11.7 SD 10 0.07 3.8 2.1 10,468 4.8 11.5 7.8 4.6 Range 58- 7.19- 0- 1.8- 3,414- 0- 5.8- 5.7- 4.9-90 7.43 13.8 9.5 36,057 14 42.3 36.2 22.3 SD = standard deviation, BD = base deficit, Lact = lactate (mg/dl), Vol = cc's/1st 24 hours, RBC = units blood/1st 24 hours. Using the Tukey Test Endo 1 levels are significantly from Endo 2 and 3, but not different between Endo 2 and 3. Endo levels did not correlate strongly with any measured admission parameter by Pearson Product moment correlation. BP pH BD Lact Vol RBC Temp HCO3 WBC r -0.15 -0.004 -0.1 -0.08 -0.18 0.15 0.4 0.15 0.3 Temp = temperature, HCO3 = bicarbonate, WBC = white blood cell count. Conclusions: The endotheiium has an immediate role in the response to hypotension after injury by releasing Endothelin-1; this did not correlate with other clinical parameters of degree of hypotension. Endothelin - 1 levels decline quickly after resuscitation.

Original languageEnglish (US)
JournalCritical Care Medicine
Volume27
Issue number1 SUPPL.
StatePublished - Dec 1 1999

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Endothelin-1
Wounds and Injuries
Endothelin-3
Endothelin-2
Hypotension
Resuscitation
Bicarbonates
Vasoconstriction
Leukocyte Count
Radioimmunoassay
Lactic Acid

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

Endothelin -1 levels in hypotensive trauma patients. / Daley, Brian; Enderson, Blaine; Hunter, Karen S.; Cruz, Edgar.

In: Critical Care Medicine, Vol. 27, No. 1 SUPPL., 01.12.1999.

Research output: Contribution to journalArticle

Daley, Brian ; Enderson, Blaine ; Hunter, Karen S. ; Cruz, Edgar. / Endothelin -1 levels in hypotensive trauma patients. In: Critical Care Medicine. 1999 ; Vol. 27, No. 1 SUPPL.
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abstract = "Objective: Measure the endothelial-released mediator of vasoconstriction, Endothelin-1 (Endo) in trauma patients with low blood pressures (BP in mm Hg). Methods: Over three months, 15 patients with initial BP < 90 had serum sampled on admission (Endo 1), and days 2 and 7 (Endo 2 and 3) after resuscitation. Endo levels were assayed by radioimmunoassay (Pennisula Labs, Belmont, CA). Results: Mean age was 55 years (25-84); there were 9 men and 6 women. BP pH BD Lact Vol RBC Endo Endo Endo 3 1 2 mean 75 7.34 4.2 4.0 12,159 5.9 24.7 17.1 11.7 SD 10 0.07 3.8 2.1 10,468 4.8 11.5 7.8 4.6 Range 58- 7.19- 0- 1.8- 3,414- 0- 5.8- 5.7- 4.9-90 7.43 13.8 9.5 36,057 14 42.3 36.2 22.3 SD = standard deviation, BD = base deficit, Lact = lactate (mg/dl), Vol = cc's/1st 24 hours, RBC = units blood/1st 24 hours. Using the Tukey Test Endo 1 levels are significantly from Endo 2 and 3, but not different between Endo 2 and 3. Endo levels did not correlate strongly with any measured admission parameter by Pearson Product moment correlation. BP pH BD Lact Vol RBC Temp HCO3 WBC r -0.15 -0.004 -0.1 -0.08 -0.18 0.15 0.4 0.15 0.3 Temp = temperature, HCO3 = bicarbonate, WBC = white blood cell count. Conclusions: The endotheiium has an immediate role in the response to hypotension after injury by releasing Endothelin-1; this did not correlate with other clinical parameters of degree of hypotension. Endothelin - 1 levels decline quickly after resuscitation.",
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AB - Objective: Measure the endothelial-released mediator of vasoconstriction, Endothelin-1 (Endo) in trauma patients with low blood pressures (BP in mm Hg). Methods: Over three months, 15 patients with initial BP < 90 had serum sampled on admission (Endo 1), and days 2 and 7 (Endo 2 and 3) after resuscitation. Endo levels were assayed by radioimmunoassay (Pennisula Labs, Belmont, CA). Results: Mean age was 55 years (25-84); there were 9 men and 6 women. BP pH BD Lact Vol RBC Endo Endo Endo 3 1 2 mean 75 7.34 4.2 4.0 12,159 5.9 24.7 17.1 11.7 SD 10 0.07 3.8 2.1 10,468 4.8 11.5 7.8 4.6 Range 58- 7.19- 0- 1.8- 3,414- 0- 5.8- 5.7- 4.9-90 7.43 13.8 9.5 36,057 14 42.3 36.2 22.3 SD = standard deviation, BD = base deficit, Lact = lactate (mg/dl), Vol = cc's/1st 24 hours, RBC = units blood/1st 24 hours. Using the Tukey Test Endo 1 levels are significantly from Endo 2 and 3, but not different between Endo 2 and 3. Endo levels did not correlate strongly with any measured admission parameter by Pearson Product moment correlation. BP pH BD Lact Vol RBC Temp HCO3 WBC r -0.15 -0.004 -0.1 -0.08 -0.18 0.15 0.4 0.15 0.3 Temp = temperature, HCO3 = bicarbonate, WBC = white blood cell count. Conclusions: The endotheiium has an immediate role in the response to hypotension after injury by releasing Endothelin-1; this did not correlate with other clinical parameters of degree of hypotension. Endothelin - 1 levels decline quickly after resuscitation.

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