Endothelins and NADPH oxidases in the cardiovascular system

Karigowda J. Dammanahalli, Zhongjie Sun

Research output: Contribution to journalShort survey

33 Citations (Scopus)

Abstract

1. The endothelin (ET) system and NADPH oxidase play important roles in the regulation of cardiovascular function, as well as in the pathogenesis of hypertension and other cardiovascular diseases. 2. Endothelins activate NADPH oxidases and thereby increase superoxide production, resulting in oxidative stress and cardiovascular dysfunction. Thus, NADPH oxidases may mediate the role of endothelins in some cardiovascular diseases. However, the role of reactive oxygen species (ROS) in mediating ET-induced vasoconstriction and cardiovascular disease remains under debate, as evidenced by conflicting reports from different research teams. Conversely, activation of NADPH oxidase can stimulate ET secretion via ROS generation, which further enhances the cardiovascular effects of NADPH oxidase. However, little is known about how ROS activate the endothelin system. It seems that the relationship between ET-1 and ROS may vary with cardiovascular disorders. 3. Endothelins activate NADPH oxidase via the ET receptor-proline-rich tyrosine kinase-2 (Pyk2)-Rac1 pathway. Rac1 is an important regulator of NADPH oxidase. There is ample evidence supporting direct stimulation by Rac1 of NADPH oxidase activity. In addition, Rac1-induced cardiomyocyte hypertrophy is mediated by the generation of ROS.

Original languageEnglish (US)
Pages (from-to)2-6
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2008

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NADPH Oxidase
Endothelins
Cardiovascular System
Reactive Oxygen Species
Cardiovascular Diseases
Focal Adhesion Kinase 2
Endothelin Receptors
Endothelin-1
Vasoconstriction
Cardiac Myocytes
Superoxides
Hypertrophy
Oxidative Stress
Hypertension
Research

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Endothelins and NADPH oxidases in the cardiovascular system. / Dammanahalli, Karigowda J.; Sun, Zhongjie.

In: Clinical and Experimental Pharmacology and Physiology, Vol. 35, No. 1, 01.01.2008, p. 2-6.

Research output: Contribution to journalShort survey

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