Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor

David M. Savastano, Marian Tanofsky-Kraff, Joan Han, Cong Ning, Rachael A. Sorg, Caroline A. Roza, Laura E. Wolkoff, Kavitha Anandalingam, Kyra S. Jefferson-George, Roberto E. Figueroa, Ethan L. Sanford, Sheila Brady, Merel Kozlosky, Dale A. Schoeller, Jack A. Yanovski

Research output: Contribution to journalArticle

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Abstract

Background: Homozygosity for 2 protein-altering polymorphisms in the melanocortin-3 receptor gene (MC3R) coding sequence, C17A and G241A, has been reported to be associated with an obesity phenotype in children, yet how these polymorphisms affect energy homeostasis is unknown. Association between adult body weight and +2138InsCAGACC, another variant in the 3′ untranslated region of MC3R, has also been described. Objective: The objective of this study was to examine associations of C17A + G241A and +2138InsCAGACC MC3R variants with children's energy balance. Design: Children aged 6-19 y were genotyped for MC3R C17A, G241A, and +2138InsCAGACC. Subjects underwent studies of energy intake from a 9835-kcal food array (n = 185), resting energy expenditure (REE) by using indirect calorimetry (n = 302), or total daily energy expenditure (TEE) by using doubly labeled water (n = 120). Linear regression was used to examine the associations between MC3R polymorphisms and the measures of energy balance. Results: Body mass index and fat mass were greater in those with double homozygosity for C17A + G241A (P = 0.001). After accounting for covariates (including body composition), the number of minor C17A + G241A alleles was associated with significantly greater energy intake (β = +0.15, P = 0.02) but not altered REE or TEE. No significant associations were observed between +2138InsCAGACC and measures of either fat mass or energy balance. Conclusions: C17A + G241A polymorphisms may be associated with pediatric obesity because of greater energy intake rather than because of diminished energy expenditure. +2138InsCAGACC does not appear to be associated with obesity or measures of energy balance in children.

Original languageEnglish (US)
Pages (from-to)912-920
Number of pages9
JournalAmerican Journal of Clinical Nutrition
Volume90
Issue number4
DOIs
StatePublished - Oct 1 2009

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Receptor, Melanocortin, Type 3
Energy Intake
Energy Metabolism
Genes
Obesity
Fats
Indirect Calorimetry
Pediatric Obesity
3' Untranslated Regions
Body Composition
Linear Models
Body Mass Index
Homeostasis
Alleles
Body Weight
Phenotype
Food
Water
Proteins

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor. / Savastano, David M.; Tanofsky-Kraff, Marian; Han, Joan; Ning, Cong; Sorg, Rachael A.; Roza, Caroline A.; Wolkoff, Laura E.; Anandalingam, Kavitha; Jefferson-George, Kyra S.; Figueroa, Roberto E.; Sanford, Ethan L.; Brady, Sheila; Kozlosky, Merel; Schoeller, Dale A.; Yanovski, Jack A.

In: American Journal of Clinical Nutrition, Vol. 90, No. 4, 01.10.2009, p. 912-920.

Research output: Contribution to journalArticle

Savastano, DM, Tanofsky-Kraff, M, Han, J, Ning, C, Sorg, RA, Roza, CA, Wolkoff, LE, Anandalingam, K, Jefferson-George, KS, Figueroa, RE, Sanford, EL, Brady, S, Kozlosky, M, Schoeller, DA & Yanovski, JA 2009, 'Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor', American Journal of Clinical Nutrition, vol. 90, no. 4, pp. 912-920. https://doi.org/10.3945/ajcn.2009.27537
Savastano, David M. ; Tanofsky-Kraff, Marian ; Han, Joan ; Ning, Cong ; Sorg, Rachael A. ; Roza, Caroline A. ; Wolkoff, Laura E. ; Anandalingam, Kavitha ; Jefferson-George, Kyra S. ; Figueroa, Roberto E. ; Sanford, Ethan L. ; Brady, Sheila ; Kozlosky, Merel ; Schoeller, Dale A. ; Yanovski, Jack A. / Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor. In: American Journal of Clinical Nutrition. 2009 ; Vol. 90, No. 4. pp. 912-920.
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abstract = "Background: Homozygosity for 2 protein-altering polymorphisms in the melanocortin-3 receptor gene (MC3R) coding sequence, C17A and G241A, has been reported to be associated with an obesity phenotype in children, yet how these polymorphisms affect energy homeostasis is unknown. Association between adult body weight and +2138InsCAGACC, another variant in the 3′ untranslated region of MC3R, has also been described. Objective: The objective of this study was to examine associations of C17A + G241A and +2138InsCAGACC MC3R variants with children's energy balance. Design: Children aged 6-19 y were genotyped for MC3R C17A, G241A, and +2138InsCAGACC. Subjects underwent studies of energy intake from a 9835-kcal food array (n = 185), resting energy expenditure (REE) by using indirect calorimetry (n = 302), or total daily energy expenditure (TEE) by using doubly labeled water (n = 120). Linear regression was used to examine the associations between MC3R polymorphisms and the measures of energy balance. Results: Body mass index and fat mass were greater in those with double homozygosity for C17A + G241A (P = 0.001). After accounting for covariates (including body composition), the number of minor C17A + G241A alleles was associated with significantly greater energy intake (β = +0.15, P = 0.02) but not altered REE or TEE. No significant associations were observed between +2138InsCAGACC and measures of either fat mass or energy balance. Conclusions: C17A + G241A polymorphisms may be associated with pediatric obesity because of greater energy intake rather than because of diminished energy expenditure. +2138InsCAGACC does not appear to be associated with obesity or measures of energy balance in children.",
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T1 - Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor

AU - Savastano, David M.

AU - Tanofsky-Kraff, Marian

AU - Han, Joan

AU - Ning, Cong

AU - Sorg, Rachael A.

AU - Roza, Caroline A.

AU - Wolkoff, Laura E.

AU - Anandalingam, Kavitha

AU - Jefferson-George, Kyra S.

AU - Figueroa, Roberto E.

AU - Sanford, Ethan L.

AU - Brady, Sheila

AU - Kozlosky, Merel

AU - Schoeller, Dale A.

AU - Yanovski, Jack A.

PY - 2009/10/1

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N2 - Background: Homozygosity for 2 protein-altering polymorphisms in the melanocortin-3 receptor gene (MC3R) coding sequence, C17A and G241A, has been reported to be associated with an obesity phenotype in children, yet how these polymorphisms affect energy homeostasis is unknown. Association between adult body weight and +2138InsCAGACC, another variant in the 3′ untranslated region of MC3R, has also been described. Objective: The objective of this study was to examine associations of C17A + G241A and +2138InsCAGACC MC3R variants with children's energy balance. Design: Children aged 6-19 y were genotyped for MC3R C17A, G241A, and +2138InsCAGACC. Subjects underwent studies of energy intake from a 9835-kcal food array (n = 185), resting energy expenditure (REE) by using indirect calorimetry (n = 302), or total daily energy expenditure (TEE) by using doubly labeled water (n = 120). Linear regression was used to examine the associations between MC3R polymorphisms and the measures of energy balance. Results: Body mass index and fat mass were greater in those with double homozygosity for C17A + G241A (P = 0.001). After accounting for covariates (including body composition), the number of minor C17A + G241A alleles was associated with significantly greater energy intake (β = +0.15, P = 0.02) but not altered REE or TEE. No significant associations were observed between +2138InsCAGACC and measures of either fat mass or energy balance. Conclusions: C17A + G241A polymorphisms may be associated with pediatric obesity because of greater energy intake rather than because of diminished energy expenditure. +2138InsCAGACC does not appear to be associated with obesity or measures of energy balance in children.

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