Enhanced penetration of fluoride particles into bovine enamel by combining dielectrophoresis with AC electroosmosis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Fluoride deposition into the pores of enamel is necessary at high concentrations to reduce enamel demineralization and with a high degree of penetration to account for loss by ingestion. Current diffusion and electrochemical methods are inadequate for effectively transporting fluoride greater than 20 μm into enamel. The study explores the coupling of dielectrophoresis (DEP) and AC electroosmosis (ACEO) to selectively concentrate fluoride particles from fluoride gel excipients and enhance their penetration into enamel. By measuring the frequency response of approximately 10-μm-sized sodium fluoride particles in an aqueous gel media, appropriate frequencies for positive DEP, negative DEP, and ACEO are identified. An assembly composed of two cross-planar interdigitated electrode (IDE) arrays with open slots is driven successively by fields at appropriate frequencies to drive fluoride particles through the slots of the IDE and into the enamel pores using a combination of DEP and ACEO methods. Fluoride uptake and penetration of 1.23% acidulated phosphate fluoride gel into bovine tooth enamel at various depths is measured using wavelength dispersive spectrometry to compare deposition by diffusion, DEP, and DEP plus ACEO. Fluoride levels in all DEP groups were significantly higher than diffusion groups at depths 10 and 20 μm. The highest fluoride concentrations at 10, 20, 50, and 100 μm depths occur under deposition conditions combining DEP with ACEO. Fluoride levels at 50 μm were equivalent to long-term prophylactic exposure. These methods may potentially benefit populations at high risk for development of caries and periodontal disease, including underserved children and disparate groups.

Original languageEnglish (US)
Pages (from-to)2945-2955
Number of pages11
JournalElectrophoresis
Volume34
Issue number20-21
DOIs
StatePublished - Nov 1 2013

Fingerprint

Electroosmosis
Enamels
Dental Enamel
Electrophoresis
Fluorides
Gels
Acidulated Phosphate Fluoride
Electrodes
Tooth enamel
Sodium Fluoride
Excipients
Periodontal Diseases
Spectrometry
Frequency response
Spectrum Analysis
Tooth
Eating

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Cite this

Enhanced penetration of fluoride particles into bovine enamel by combining dielectrophoresis with AC electroosmosis. / Ivanoff, Chris; Swami, Nathan S.; Hottel, Timothy; Garcia-Godoy, Franklin.

In: Electrophoresis, Vol. 34, No. 20-21, 01.11.2013, p. 2945-2955.

Research output: Contribution to journalArticle

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