Enhancement of dorsal raphe discharge by medial pontine reticular formation stimulation depends on behavioral state

Ralph Lydic, R. W. McCarley, J. A. Hobson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Single cell activity was recorded with microwire electrodes from the dorsal raphe nucleus (DRN) of cats across multiple cycles of sleep and wakefulness. Electrical stimulation of the medial pontine reticular formation (mPRF) produced a 10-fold enhancement of DRN discharge during wakefulness and slow wave sleep but not during desynchronized sleep. The neuronal mechanisms likely to mediate the state-dependent effects of mPRF stimulation are discussed with regard to the hypothesis that DRN plays a major role in behavioral state control.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalNeuroscience Letters
Volume38
Issue number1
DOIs
StatePublished - Jul 15 1983
Externally publishedYes

Fingerprint

Sleep
Wakefulness
Electric Stimulation
Electrodes
Cats
Dorsal Raphe Nucleus
Pontine Tegmentum

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Enhancement of dorsal raphe discharge by medial pontine reticular formation stimulation depends on behavioral state. / Lydic, Ralph; McCarley, R. W.; Hobson, J. A.

In: Neuroscience Letters, Vol. 38, No. 1, 15.07.1983, p. 35-40.

Research output: Contribution to journalArticle

@article{75909a7877b4442e983252e3de35c679,
title = "Enhancement of dorsal raphe discharge by medial pontine reticular formation stimulation depends on behavioral state",
abstract = "Single cell activity was recorded with microwire electrodes from the dorsal raphe nucleus (DRN) of cats across multiple cycles of sleep and wakefulness. Electrical stimulation of the medial pontine reticular formation (mPRF) produced a 10-fold enhancement of DRN discharge during wakefulness and slow wave sleep but not during desynchronized sleep. The neuronal mechanisms likely to mediate the state-dependent effects of mPRF stimulation are discussed with regard to the hypothesis that DRN plays a major role in behavioral state control.",
author = "Ralph Lydic and McCarley, {R. W.} and Hobson, {J. A.}",
year = "1983",
month = "7",
day = "15",
doi = "10.1016/0304-3940(83)90106-4",
language = "English (US)",
volume = "38",
pages = "35--40",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Enhancement of dorsal raphe discharge by medial pontine reticular formation stimulation depends on behavioral state

AU - Lydic, Ralph

AU - McCarley, R. W.

AU - Hobson, J. A.

PY - 1983/7/15

Y1 - 1983/7/15

N2 - Single cell activity was recorded with microwire electrodes from the dorsal raphe nucleus (DRN) of cats across multiple cycles of sleep and wakefulness. Electrical stimulation of the medial pontine reticular formation (mPRF) produced a 10-fold enhancement of DRN discharge during wakefulness and slow wave sleep but not during desynchronized sleep. The neuronal mechanisms likely to mediate the state-dependent effects of mPRF stimulation are discussed with regard to the hypothesis that DRN plays a major role in behavioral state control.

AB - Single cell activity was recorded with microwire electrodes from the dorsal raphe nucleus (DRN) of cats across multiple cycles of sleep and wakefulness. Electrical stimulation of the medial pontine reticular formation (mPRF) produced a 10-fold enhancement of DRN discharge during wakefulness and slow wave sleep but not during desynchronized sleep. The neuronal mechanisms likely to mediate the state-dependent effects of mPRF stimulation are discussed with regard to the hypothesis that DRN plays a major role in behavioral state control.

UR - http://www.scopus.com/inward/record.url?scp=0020634249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020634249&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(83)90106-4

DO - 10.1016/0304-3940(83)90106-4

M3 - Article

VL - 38

SP - 35

EP - 40

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -