Enhancement of intratumoral chemotherapy with cisplatin with or without microwave ablation and lipiodol. future concept for local treatment in lung cancer

Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Joshua Stopek, Efstratios Kosmidis, Thomas Vogl, Bernd Linsmeier, Kosmas Tsakiridis, Sofia Lampaki, George Lazaridis, Andreas Mpakas, Robert Browning, Antonis Papaiwannou, Antonis Drevelegas, Sofia Baka, Vasilis Karavasilis, Ioannis Mpoukovinas, J. Turner, Konstantinos Zarogoulidis, Johannes Brachmann

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (106) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm3 the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

Original languageEnglish (US)
Pages (from-to)218-226
Number of pages9
JournalJournal of Cancer
Volume6
Issue number3
DOIs
StatePublished - Jan 1 2015

Fingerprint

Ethiodized Oil
Microwaves
Cisplatin
Lung Neoplasms
Drug Therapy
Therapeutics
Lewis Lung Carcinoma
Drug Combinations
Tumor Burden
Germany
Neoplasms
Leg
Magnetic Resonance Imaging
Apoptosis
Cell Line
Control Groups

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Hohenforst-Schmidt, W., Zarogoulidis, P., Stopek, J., Kosmidis, E., Vogl, T., Linsmeier, B., ... Brachmann, J. (2015). Enhancement of intratumoral chemotherapy with cisplatin with or without microwave ablation and lipiodol. future concept for local treatment in lung cancer. Journal of Cancer, 6(3), 218-226. https://doi.org/10.7150/jca.10970

Enhancement of intratumoral chemotherapy with cisplatin with or without microwave ablation and lipiodol. future concept for local treatment in lung cancer. / Hohenforst-Schmidt, Wolfgang; Zarogoulidis, Paul; Stopek, Joshua; Kosmidis, Efstratios; Vogl, Thomas; Linsmeier, Bernd; Tsakiridis, Kosmas; Lampaki, Sofia; Lazaridis, George; Mpakas, Andreas; Browning, Robert; Papaiwannou, Antonis; Drevelegas, Antonis; Baka, Sofia; Karavasilis, Vasilis; Mpoukovinas, Ioannis; Turner, J.; Zarogoulidis, Konstantinos; Brachmann, Johannes.

In: Journal of Cancer, Vol. 6, No. 3, 01.01.2015, p. 218-226.

Research output: Contribution to journalArticle

Hohenforst-Schmidt, W, Zarogoulidis, P, Stopek, J, Kosmidis, E, Vogl, T, Linsmeier, B, Tsakiridis, K, Lampaki, S, Lazaridis, G, Mpakas, A, Browning, R, Papaiwannou, A, Drevelegas, A, Baka, S, Karavasilis, V, Mpoukovinas, I, Turner, J, Zarogoulidis, K & Brachmann, J 2015, 'Enhancement of intratumoral chemotherapy with cisplatin with or without microwave ablation and lipiodol. future concept for local treatment in lung cancer', Journal of Cancer, vol. 6, no. 3, pp. 218-226. https://doi.org/10.7150/jca.10970
Hohenforst-Schmidt, Wolfgang ; Zarogoulidis, Paul ; Stopek, Joshua ; Kosmidis, Efstratios ; Vogl, Thomas ; Linsmeier, Bernd ; Tsakiridis, Kosmas ; Lampaki, Sofia ; Lazaridis, George ; Mpakas, Andreas ; Browning, Robert ; Papaiwannou, Antonis ; Drevelegas, Antonis ; Baka, Sofia ; Karavasilis, Vasilis ; Mpoukovinas, Ioannis ; Turner, J. ; Zarogoulidis, Konstantinos ; Brachmann, Johannes. / Enhancement of intratumoral chemotherapy with cisplatin with or without microwave ablation and lipiodol. future concept for local treatment in lung cancer. In: Journal of Cancer. 2015 ; Vol. 6, No. 3. pp. 218-226.
@article{18e6a9c3268e40da9f235878bb7a61ab,
title = "Enhancement of intratumoral chemotherapy with cisplatin with or without microwave ablation and lipiodol. future concept for local treatment in lung cancer",
abstract = "Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (106) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm3 the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.",
author = "Wolfgang Hohenforst-Schmidt and Paul Zarogoulidis and Joshua Stopek and Efstratios Kosmidis and Thomas Vogl and Bernd Linsmeier and Kosmas Tsakiridis and Sofia Lampaki and George Lazaridis and Andreas Mpakas and Robert Browning and Antonis Papaiwannou and Antonis Drevelegas and Sofia Baka and Vasilis Karavasilis and Ioannis Mpoukovinas and J. Turner and Konstantinos Zarogoulidis and Johannes Brachmann",
year = "2015",
month = "1",
day = "1",
doi = "10.7150/jca.10970",
language = "English (US)",
volume = "6",
pages = "218--226",
journal = "Journal of Cancer",
issn = "1837-9664",
publisher = "Ivyspring International Publisher",
number = "3",

}

TY - JOUR

T1 - Enhancement of intratumoral chemotherapy with cisplatin with or without microwave ablation and lipiodol. future concept for local treatment in lung cancer

AU - Hohenforst-Schmidt, Wolfgang

AU - Zarogoulidis, Paul

AU - Stopek, Joshua

AU - Kosmidis, Efstratios

AU - Vogl, Thomas

AU - Linsmeier, Bernd

AU - Tsakiridis, Kosmas

AU - Lampaki, Sofia

AU - Lazaridis, George

AU - Mpakas, Andreas

AU - Browning, Robert

AU - Papaiwannou, Antonis

AU - Drevelegas, Antonis

AU - Baka, Sofia

AU - Karavasilis, Vasilis

AU - Mpoukovinas, Ioannis

AU - Turner, J.

AU - Zarogoulidis, Konstantinos

AU - Brachmann, Johannes

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (106) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm3 the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

AB - Novel therapies for lung cancer are being explored nowadays with local therapies being the tip of the arrow. Intratumoral chemotherapy administration and local microwave ablation have been investigated in several studies. It has been previously proposed that lipiodol has the ability to modify the microenvironment matrix. In our current study we investigated this theory in BALBC mice. In total 160 BALBC mice were divided in eight groups: a) control, b) cisplatin, c) microwave, d) microwave and lipiodol, e) cisplatin and lipiodol, f) microwave and cisplatin, g) lipiodol and h) lipiodol, cisplatin and microwave. Lewis lung carcinoma cell lines (106) were injected into the right back leg of each mouse. After the 8th day, when the tumor volume was about 100mm3 the therapy application was initiated, once per week for four weeks. Magnetic resonance imaging was performed for each tumor when a mouse died or when sacrificed if they were still alive by the end of the experiment (8-Canal multifunctional spool; NORAS MRI products, Gmbh, Germany). Imaging and survival revealed efficient tumor apoptosis for the groups b,c,d,e and f. However; severe toxicity was observed in group h and no follow up was available for this group after the second week of therapy administration. Lipiodol in its current form does assist in a more efficient way the distribution of cisplatin, as the microwave apoptotic effect. Future modification of lipiodol might provide a more efficient method of therapy enhancement. Combination of drug and microwave ablation is possible and has an efficient apoptotic effect.

UR - http://www.scopus.com/inward/record.url?scp=84923687137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923687137&partnerID=8YFLogxK

U2 - 10.7150/jca.10970

DO - 10.7150/jca.10970

M3 - Article

VL - 6

SP - 218

EP - 226

JO - Journal of Cancer

JF - Journal of Cancer

SN - 1837-9664

IS - 3

ER -