Enterobacter sakazakii infections in neonates associated with intrinsic contamination of a powdered infant formula

Bryan P. Simmons, Michael Gelfand, Michael Haas, Linda Metts, John Ferguson

Research output: Contribution to journalArticle

213 Citations (Scopus)

Abstract

We report an outbreak of Enterobacter sakazakii infection and colonization in neonates related to an infant formula contaminated during the manufacturing process. The outbreak occurred in a 20-bed neonatal intensive care unit during a six-week period in 1988, and involved a total of four infants. Three infants had sepsis and three had bloody diarrhea; all patients responded to intravenous antibiotics and recovered without complications. The E sakazakii isolated from the formula had the same plasmid and multilocus enzyme profile as those isolated from patients. This outbreak demonstrates the significance of commercially contaminated formulas and emphasizes the need to limit contamination and multiplication of bacteria in enteral formulas.

Original languageEnglish (US)
Pages (from-to)398-401
Number of pages4
JournalInfection Control & Hospital Epidemiology
Volume10
Issue number9
DOIs
StatePublished - Jan 1 1989

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Cronobacter sakazakii
Infant Formula
Disease Outbreaks
Newborn Infant
Infection
Neonatal Intensive Care Units
Small Intestine
Diarrhea
Sepsis
Plasmids
Anti-Bacterial Agents
Bacteria
Enzymes

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Enterobacter sakazakii infections in neonates associated with intrinsic contamination of a powdered infant formula. / Simmons, Bryan P.; Gelfand, Michael; Haas, Michael; Metts, Linda; Ferguson, John.

In: Infection Control & Hospital Epidemiology, Vol. 10, No. 9, 01.01.1989, p. 398-401.

Research output: Contribution to journalArticle

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