Ephaptic interactions in the mammalian olfactory system.

H. Bokil, N. Laaris, K. Blinder, Matthew Ennis, A. Keller

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Ephaptic coupling refers to interactions between neurons mediated by current flow through the extracellular space. Ephaptic interactions between axons are considered negligible, because of the relatively large extracellular space and the layers of myelin that separate most axons. By contrast, olfactory nerve axons are unmyelinated and arranged in tightly packed bundles, features that may enhance ephaptic coupling. We tested the hypothesis that ephaptic interactions occur in the mammalian olfactory nerve with the use of a computational approach. Numerical solutions of models of axon fascicles show that significant ephaptic interactions occur for a range of physiologically relevant parameters. An action potential in a single axon can evoke action potentials in all other axons in the fascicle. Ephaptic interactions can also lead to synchronized firing of independently stimulated axons. Our findings suggest that ephaptic interactions may be significant determinants of the olfactory code and that such interactions may occur in other, similarly organized axonal or dendritic bundles.

Original languageEnglish (US)
JournalThe Journal of neuroscience : the official journal of the Society for Neuroscience
Volume21
Issue number20
StatePublished - Jan 1 2001

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Axons
Olfactory Nerve
Extracellular Space
Action Potentials
Myelin Sheath
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Ephaptic interactions in the mammalian olfactory system. / Bokil, H.; Laaris, N.; Blinder, K.; Ennis, Matthew; Keller, A.

In: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, No. 20, 01.01.2001.

Research output: Contribution to journalArticle

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