Epidermal growth factor EGF in human saliva

Effect of age, sex, race, pregnancy and sialagogue

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Saliva samples were obtained from volunteers either by spontaneous expectoration or after stimulation with citric acid (5% and EGF was measured by a homologous radioimmounoassay. The mean ± SEM of salivary human epidermal growth factor (hEGF) concentration in 70 males (aged 19-41) was 368.71 ±28.55 pmol/1 and 417.67 + 37.61 pmol/1 in 55 females (aged 19-45), P0.5. Values were found undetectable (32 pmol/1 in 6 prepubertal children. There was a tendency for hEGF to rise with age from about middle age but no significant racial or pregnancy related changes were observed. Stimulated sallivation with citric acid caused a fall in hEGF through a dilution effect. These results show that age has an important influence on the hEGF concentration of resting saliva.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalScandinavian Journal of Gastroenterology
Volume21
Issue numberS124
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Saliva
Epidermal Growth Factor
Pregnancy
Citric Acid
Volunteers

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Gastroenterology

Cite this

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title = "Epidermal growth factor EGF in human saliva: Effect of age, sex, race, pregnancy and sialagogue",
abstract = "Saliva samples were obtained from volunteers either by spontaneous expectoration or after stimulation with citric acid (5{\%} and EGF was measured by a homologous radioimmounoassay. The mean ± SEM of salivary human epidermal growth factor (hEGF) concentration in 70 males (aged 19-41) was 368.71 ±28.55 pmol/1 and 417.67 + 37.61 pmol/1 in 55 females (aged 19-45), P0.5. Values were found undetectable (32 pmol/1 in 6 prepubertal children. There was a tendency for hEGF to rise with age from about middle age but no significant racial or pregnancy related changes were observed. Stimulated sallivation with citric acid caused a fall in hEGF through a dilution effect. These results show that age has an important influence on the hEGF concentration of resting saliva.",
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T1 - Epidermal growth factor EGF in human saliva

T2 - Effect of age, sex, race, pregnancy and sialagogue

AU - Dagogo-Jack, Samuel

PY - 1986/1/1

Y1 - 1986/1/1

N2 - Saliva samples were obtained from volunteers either by spontaneous expectoration or after stimulation with citric acid (5% and EGF was measured by a homologous radioimmounoassay. The mean ± SEM of salivary human epidermal growth factor (hEGF) concentration in 70 males (aged 19-41) was 368.71 ±28.55 pmol/1 and 417.67 + 37.61 pmol/1 in 55 females (aged 19-45), P0.5. Values were found undetectable (32 pmol/1 in 6 prepubertal children. There was a tendency for hEGF to rise with age from about middle age but no significant racial or pregnancy related changes were observed. Stimulated sallivation with citric acid caused a fall in hEGF through a dilution effect. These results show that age has an important influence on the hEGF concentration of resting saliva.

AB - Saliva samples were obtained from volunteers either by spontaneous expectoration or after stimulation with citric acid (5% and EGF was measured by a homologous radioimmounoassay. The mean ± SEM of salivary human epidermal growth factor (hEGF) concentration in 70 males (aged 19-41) was 368.71 ±28.55 pmol/1 and 417.67 + 37.61 pmol/1 in 55 females (aged 19-45), P0.5. Values were found undetectable (32 pmol/1 in 6 prepubertal children. There was a tendency for hEGF to rise with age from about middle age but no significant racial or pregnancy related changes were observed. Stimulated sallivation with citric acid caused a fall in hEGF through a dilution effect. These results show that age has an important influence on the hEGF concentration of resting saliva.

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