Epinephrine enantiomers

Affinity, efficacy and potency relationships in rat smooth muscle tissues

P. J. Rice, Duane Miller, P. N. Patil

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The purpose of this study was to examine the relationship between affinity and efficacy for the epinephrine enantiomers in rat tissues. Potency and was measured for (-)- and (+)-epinephrine in aorta, longitudinal muscle of portal vein, spleen and vas deferens. After partial alpha-adrenoceptor inactivation with phenoxybenzamine, dissociation constant was estimated for each enantiomer and used to estimate efficacy. Whereas potency, affinity and efficacy vary between tissues, there is a constant relationship between (-)- and (+)-enantiomer; the enantiomeric ratio is constant for both potency and affinity. Efficacy is similar for the enantiomers in each tissue. The potency difference between epinephrine enantiomers at alpha-adrenoceptors in rat tissues is due to differences in affinity rather than efficacy.

Original languageEnglish (US)
Pages (from-to)242-248
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume249
Issue number1
StatePublished - 1989
Externally publishedYes

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Epinephrine
Smooth Muscle
Muscles
Adrenergic Receptors
Phenoxybenzamine
Vas Deferens
Portal Vein
Aorta
Spleen

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Epinephrine enantiomers : Affinity, efficacy and potency relationships in rat smooth muscle tissues. / Rice, P. J.; Miller, Duane; Patil, P. N.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 249, No. 1, 1989, p. 242-248.

Research output: Contribution to journalArticle

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