Epithelioid sarcoma: results of conservative surgery and radiotherapy

Matthew D. Callister, Matthew Ballo, Peter W.T. Pisters, Shreyaskumar R. Patel, Barry W. Feig, Raphael E. Pollock, Robert S. Benjamin, Gunar K. Zagars

Research output: Contribution to journalArticle

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Abstract

Purpose: To determine the outcome and prognostic factors for patients with localized epithelioid sarcoma treated with conservative surgery and radiotherapy (RT).Methods and Materials: The medical records of 24 patients with nonmetastatic epithelioid sarcoma treated with conservative surgery and RT were reviewed. Preoperative RT was given to 3 patients (median 46.4 Gy) and postoperative RT to 21 patients (median 64.5 Gy). A local (limb-sparing) surgical procedure was performed in all patients.Results: At a median follow-up of 131 months, 14 patients had relapsed and 13 patients had died. The actuarial overall and disease-free survival rate at 10 years was 50% and 37%, respectively. Local, nodal, and metastatic failure occurred in 7, 4, and 10 patients, respectively, yielding a 10-year actuarial local, nodal, and metastatic control rate of 63%, 81%, and 56%, respectively. Univariate analysis revealed that size ≤5 cm and extremity location were favorable prognostic factors for overall, disease-free, and metastasis-free survival. The actuarial 5-year overall, disease-free, and metastasis-free survival rate was 79% vs. 25% (p = 0.002), 51% vs. 13% (p = 0.03), and 79% vs. 13% (p <0.001), respectively, for lesion size ≤5 vs. > 5 cm. The actuarial 5-year overall, disease-free, and metastasis-free survival rate was 77% vs. 39% (p = 0.002), 56% vs. 0% (p = 0.01), and 78% vs. 17% (p = 0.01), respectively, for extremity vs. nonextremity location. Multivariate analysis of the factors correlating with the overall, disease-free, and metastasis-free survival confirmed the favorable prognostic significance of small lesion size. The prognostic significance of extremity location on univariate analysis was explained by an imbalance in the mean tumor sizes. Conclusions: Epithelioid sarcoma is an aggressive soft-tissue sarcoma, with high rates of local and distant relapse. Local control with conservative surgery and RT compares favorably to published surgical series. The poor outcome for tumors ≥5 cm in size emphasizes the need for effective systemic therapy.

Original languageEnglish (US)
Pages (from-to)384-391
Number of pages8
JournalInternational Journal of Radiation Oncology Biology Physics
Volume51
Issue number2
DOIs
StatePublished - Oct 1 2001

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surgery
Sarcoma
radiation therapy
Radiotherapy
cancer
metastasis
Extremities
Neoplasm Metastasis
Survival Rate
tumors
Survival
limbs
lesions
Disease-Free Survival
Medical Records
therapy
Neoplasms
Multivariate Analysis
Recurrence

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Callister, M. D., Ballo, M., Pisters, P. W. T., Patel, S. R., Feig, B. W., Pollock, R. E., ... Zagars, G. K. (2001). Epithelioid sarcoma: results of conservative surgery and radiotherapy. International Journal of Radiation Oncology Biology Physics, 51(2), 384-391. https://doi.org/10.1016/S0360-3016(01)01646-7

Epithelioid sarcoma : results of conservative surgery and radiotherapy. / Callister, Matthew D.; Ballo, Matthew; Pisters, Peter W.T.; Patel, Shreyaskumar R.; Feig, Barry W.; Pollock, Raphael E.; Benjamin, Robert S.; Zagars, Gunar K.

In: International Journal of Radiation Oncology Biology Physics, Vol. 51, No. 2, 01.10.2001, p. 384-391.

Research output: Contribution to journalArticle

Callister, MD, Ballo, M, Pisters, PWT, Patel, SR, Feig, BW, Pollock, RE, Benjamin, RS & Zagars, GK 2001, 'Epithelioid sarcoma: results of conservative surgery and radiotherapy', International Journal of Radiation Oncology Biology Physics, vol. 51, no. 2, pp. 384-391. https://doi.org/10.1016/S0360-3016(01)01646-7
Callister, Matthew D. ; Ballo, Matthew ; Pisters, Peter W.T. ; Patel, Shreyaskumar R. ; Feig, Barry W. ; Pollock, Raphael E. ; Benjamin, Robert S. ; Zagars, Gunar K. / Epithelioid sarcoma : results of conservative surgery and radiotherapy. In: International Journal of Radiation Oncology Biology Physics. 2001 ; Vol. 51, No. 2. pp. 384-391.
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AU - Feig, Barry W.

AU - Pollock, Raphael E.

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AU - Zagars, Gunar K.

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N2 - Purpose: To determine the outcome and prognostic factors for patients with localized epithelioid sarcoma treated with conservative surgery and radiotherapy (RT).Methods and Materials: The medical records of 24 patients with nonmetastatic epithelioid sarcoma treated with conservative surgery and RT were reviewed. Preoperative RT was given to 3 patients (median 46.4 Gy) and postoperative RT to 21 patients (median 64.5 Gy). A local (limb-sparing) surgical procedure was performed in all patients.Results: At a median follow-up of 131 months, 14 patients had relapsed and 13 patients had died. The actuarial overall and disease-free survival rate at 10 years was 50% and 37%, respectively. Local, nodal, and metastatic failure occurred in 7, 4, and 10 patients, respectively, yielding a 10-year actuarial local, nodal, and metastatic control rate of 63%, 81%, and 56%, respectively. Univariate analysis revealed that size ≤5 cm and extremity location were favorable prognostic factors for overall, disease-free, and metastasis-free survival. The actuarial 5-year overall, disease-free, and metastasis-free survival rate was 79% vs. 25% (p = 0.002), 51% vs. 13% (p = 0.03), and 79% vs. 13% (p <0.001), respectively, for lesion size ≤5 vs. > 5 cm. The actuarial 5-year overall, disease-free, and metastasis-free survival rate was 77% vs. 39% (p = 0.002), 56% vs. 0% (p = 0.01), and 78% vs. 17% (p = 0.01), respectively, for extremity vs. nonextremity location. Multivariate analysis of the factors correlating with the overall, disease-free, and metastasis-free survival confirmed the favorable prognostic significance of small lesion size. The prognostic significance of extremity location on univariate analysis was explained by an imbalance in the mean tumor sizes. Conclusions: Epithelioid sarcoma is an aggressive soft-tissue sarcoma, with high rates of local and distant relapse. Local control with conservative surgery and RT compares favorably to published surgical series. The poor outcome for tumors ≥5 cm in size emphasizes the need for effective systemic therapy.

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