Equivalence Lack in Digoxin Plasma Levels

John G. Wagner, Marianne Christensen, Ermelinda Sakmar, Donald Blair, James Yates, Park W. Willis, Allen J. Sedman, Roger G. Stoll

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

In an eight-subject two-way crossover study, 0.5-mg oral doses of digoxin were administered as two 0.25-mg tablets made by two different manufacturers. Treatment “B” yielded average peak plasma levels and areas under the curves that were 59% and 55%, respectively, of those attained following treatment “A”. Two of the eight subjects also received the same dose in 5% dextrose both orally and by constant rate intravenous infusion during a one-hour period. Average peaks were 4.19, 3.76, 1.46, and 0.70 ng/ml following the intravenous infusion, solution orally, treatment A (tablet) orally, and treatment B (tablet) orally, respectively. Relative areas under the curves were 100%, 80.2%, 56.7%, and 30.7% for the treatments in the same order.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalJAMA: The Journal of the American Medical Association
Volume224
Issue number2
DOIs
StatePublished - Apr 9 1973
Externally publishedYes

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Digoxin
Tablets
Intravenous Infusions
Area Under Curve
Therapeutics
Cross-Over Studies
Glucose

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Wagner, J. G., Christensen, M., Sakmar, E., Blair, D., Yates, J., Willis, P. W., ... Stoll, R. G. (1973). Equivalence Lack in Digoxin Plasma Levels. JAMA: The Journal of the American Medical Association, 224(2), 199-204. https://doi.org/10.1001/jama.1973.03220150013004

Equivalence Lack in Digoxin Plasma Levels. / Wagner, John G.; Christensen, Marianne; Sakmar, Ermelinda; Blair, Donald; Yates, James; Willis, Park W.; Sedman, Allen J.; Stoll, Roger G.

In: JAMA: The Journal of the American Medical Association, Vol. 224, No. 2, 09.04.1973, p. 199-204.

Research output: Contribution to journalArticle

Wagner, JG, Christensen, M, Sakmar, E, Blair, D, Yates, J, Willis, PW, Sedman, AJ & Stoll, RG 1973, 'Equivalence Lack in Digoxin Plasma Levels', JAMA: The Journal of the American Medical Association, vol. 224, no. 2, pp. 199-204. https://doi.org/10.1001/jama.1973.03220150013004
Wagner, John G. ; Christensen, Marianne ; Sakmar, Ermelinda ; Blair, Donald ; Yates, James ; Willis, Park W. ; Sedman, Allen J. ; Stoll, Roger G. / Equivalence Lack in Digoxin Plasma Levels. In: JAMA: The Journal of the American Medical Association. 1973 ; Vol. 224, No. 2. pp. 199-204.
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