Erythrocyte membrane fluidity in patients with preeclampsia and the HELLP syndrome

A preliminary study

L. Sanchez-Ramos, Charles Adair, J. C. Todd, D. L. Mollitt, D. K. Briones

Research output: Contribution to journalArticle

Abstract

Objective: To assess maternal erythrocyte membrane fluidity in patients with severe preeclampsia and normotensive pregnant controls. Methods: Eighteen patients were studied at 28-38 weeks' gestation: nine severe preeclamptics, four of whom subsequently developed HELLP syndrome, and nine normotensive pregnant women. Erythrocytes were prepared with a fluorescent lipophilic probe to measure membrane fluidity. Results: Erythrocyte membrane fluidity was higher in patients with HELLP syndrome than in severe preeclamptic and normotensive women. Conclusion: Erythrocyte membrane fluidity appears to be increased in patients with HELLP syndrome. This may play an important role in the development of microangiopathic anemia and tissue ischemia which characterize the HELLP syndrome.

Original languageEnglish (US)
Pages (from-to)237-239
Number of pages3
JournalJournal of Maternal-Fetal Investigation
Volume4
Issue number4
StatePublished - 1994
Externally publishedYes

Fingerprint

HELLP Syndrome
Membrane Fluidity
Erythrocyte Membrane
Pre-Eclampsia
Hemolytic Anemia
Fluorescent Dyes
Pregnant Women
Ischemia
Erythrocytes
Mothers
Pregnancy

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Erythrocyte membrane fluidity in patients with preeclampsia and the HELLP syndrome : A preliminary study. / Sanchez-Ramos, L.; Adair, Charles; Todd, J. C.; Mollitt, D. L.; Briones, D. K.

In: Journal of Maternal-Fetal Investigation, Vol. 4, No. 4, 1994, p. 237-239.

Research output: Contribution to journalArticle

Sanchez-Ramos, L. ; Adair, Charles ; Todd, J. C. ; Mollitt, D. L. ; Briones, D. K. / Erythrocyte membrane fluidity in patients with preeclampsia and the HELLP syndrome : A preliminary study. In: Journal of Maternal-Fetal Investigation. 1994 ; Vol. 4, No. 4. pp. 237-239.
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