Essential fatty acids in the treatment of dry eye

Elena S. Rosenberg, Penny Asbell

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Essential fatty acids (EFAs) play many important roles in human biology, affecting organ systems and cellular and intracellular function. Omega-3 and omega-6 EFAs are the precursors of eicosanoids, locally acting hormones involved in mediating inflammatory processes. It is largely via the production of these eicosanoids that the essential fatty acids influence human health and disease. In general, the omega-3 derived eicosanoids are anti-inflammatory while the n-6 pathway eicosanoids promote inflammation. To date, EFAs have been primarily studied with regard to systemic diseases, particularly cardiovascular disease. Currently, no dietary recommendations of EFAs for the prevention or treatment of eye disease exist. The majority of studies concerning EFAs and eye disease have focused on diseases of the retina. This article provides an overview of the current literature regarding EFAs and dry eye disease (DED). Eight studies were identified, including six randomized controlled trials. All the studies preliminarily confirmed that there is a relationship between EFA supplementation and improvement in DED. However, strong conclusions cannot be made yet because of limitations in the research reported. The role of essential fatty acids is an important topic that would benefit from a large, multicenter, randomized clinical trial powered to reach a conclusion regarding the efficacy of essential fatty acids in the treatment of dry eye disease.

Original languageEnglish (US)
Pages (from-to)18-28
Number of pages11
JournalOcular Surface
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Fingerprint

Essential Fatty Acids
Eye Diseases
Eicosanoids
Randomized Controlled Trials
Omega-6 Fatty Acids
Retina
Anti-Inflammatory Agents
Cardiovascular Diseases
Hormones
Inflammation

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Essential fatty acids in the treatment of dry eye. / Rosenberg, Elena S.; Asbell, Penny.

In: Ocular Surface, Vol. 8, No. 1, 01.01.2010, p. 18-28.

Research output: Contribution to journalArticle

Rosenberg, Elena S. ; Asbell, Penny. / Essential fatty acids in the treatment of dry eye. In: Ocular Surface. 2010 ; Vol. 8, No. 1. pp. 18-28.
@article{2271f876daec4981bcfe32b190e7ff63,
title = "Essential fatty acids in the treatment of dry eye",
abstract = "Essential fatty acids (EFAs) play many important roles in human biology, affecting organ systems and cellular and intracellular function. Omega-3 and omega-6 EFAs are the precursors of eicosanoids, locally acting hormones involved in mediating inflammatory processes. It is largely via the production of these eicosanoids that the essential fatty acids influence human health and disease. In general, the omega-3 derived eicosanoids are anti-inflammatory while the n-6 pathway eicosanoids promote inflammation. To date, EFAs have been primarily studied with regard to systemic diseases, particularly cardiovascular disease. Currently, no dietary recommendations of EFAs for the prevention or treatment of eye disease exist. The majority of studies concerning EFAs and eye disease have focused on diseases of the retina. This article provides an overview of the current literature regarding EFAs and dry eye disease (DED). Eight studies were identified, including six randomized controlled trials. All the studies preliminarily confirmed that there is a relationship between EFA supplementation and improvement in DED. However, strong conclusions cannot be made yet because of limitations in the research reported. The role of essential fatty acids is an important topic that would benefit from a large, multicenter, randomized clinical trial powered to reach a conclusion regarding the efficacy of essential fatty acids in the treatment of dry eye disease.",
author = "Rosenberg, {Elena S.} and Penny Asbell",
year = "2010",
month = "1",
day = "1",
doi = "10.1016/S1542-0124(12)70214-8",
language = "English (US)",
volume = "8",
pages = "18--28",
journal = "Ocular Surface",
issn = "1542-0124",
publisher = "Ethis Communications, Inc.",
number = "1",

}

TY - JOUR

T1 - Essential fatty acids in the treatment of dry eye

AU - Rosenberg, Elena S.

AU - Asbell, Penny

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Essential fatty acids (EFAs) play many important roles in human biology, affecting organ systems and cellular and intracellular function. Omega-3 and omega-6 EFAs are the precursors of eicosanoids, locally acting hormones involved in mediating inflammatory processes. It is largely via the production of these eicosanoids that the essential fatty acids influence human health and disease. In general, the omega-3 derived eicosanoids are anti-inflammatory while the n-6 pathway eicosanoids promote inflammation. To date, EFAs have been primarily studied with regard to systemic diseases, particularly cardiovascular disease. Currently, no dietary recommendations of EFAs for the prevention or treatment of eye disease exist. The majority of studies concerning EFAs and eye disease have focused on diseases of the retina. This article provides an overview of the current literature regarding EFAs and dry eye disease (DED). Eight studies were identified, including six randomized controlled trials. All the studies preliminarily confirmed that there is a relationship between EFA supplementation and improvement in DED. However, strong conclusions cannot be made yet because of limitations in the research reported. The role of essential fatty acids is an important topic that would benefit from a large, multicenter, randomized clinical trial powered to reach a conclusion regarding the efficacy of essential fatty acids in the treatment of dry eye disease.

AB - Essential fatty acids (EFAs) play many important roles in human biology, affecting organ systems and cellular and intracellular function. Omega-3 and omega-6 EFAs are the precursors of eicosanoids, locally acting hormones involved in mediating inflammatory processes. It is largely via the production of these eicosanoids that the essential fatty acids influence human health and disease. In general, the omega-3 derived eicosanoids are anti-inflammatory while the n-6 pathway eicosanoids promote inflammation. To date, EFAs have been primarily studied with regard to systemic diseases, particularly cardiovascular disease. Currently, no dietary recommendations of EFAs for the prevention or treatment of eye disease exist. The majority of studies concerning EFAs and eye disease have focused on diseases of the retina. This article provides an overview of the current literature regarding EFAs and dry eye disease (DED). Eight studies were identified, including six randomized controlled trials. All the studies preliminarily confirmed that there is a relationship between EFA supplementation and improvement in DED. However, strong conclusions cannot be made yet because of limitations in the research reported. The role of essential fatty acids is an important topic that would benefit from a large, multicenter, randomized clinical trial powered to reach a conclusion regarding the efficacy of essential fatty acids in the treatment of dry eye disease.

UR - http://www.scopus.com/inward/record.url?scp=77649196904&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649196904&partnerID=8YFLogxK

U2 - 10.1016/S1542-0124(12)70214-8

DO - 10.1016/S1542-0124(12)70214-8

M3 - Article

C2 - 20105404

AN - SCOPUS:77649196904

VL - 8

SP - 18

EP - 28

JO - Ocular Surface

JF - Ocular Surface

SN - 1542-0124

IS - 1

ER -