Essentially homochiral 1-silyl alcohols from the reduction of aliphatic acylsilanes with chlorodiisopinocampheylborane

John A. Soderquist, Charles L. Anderson, Edgar I. Miranda, Isaac Rivera, George Kabalka

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The enantioselective reduction of aliphatic acylsilanes with (-)-B-chlorodiisopinocampheylborane ((-)-IPC 2 BCl) provides (R)-1-silylated alcohols (3) in high enantiomeric excess (96-98%) in good isolated yields (59-67%).

Original languageEnglish (US)
Pages (from-to)4677-4680
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number33
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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Alcohols

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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Essentially homochiral 1-silyl alcohols from the reduction of aliphatic acylsilanes with chlorodiisopinocampheylborane. / Soderquist, John A.; Anderson, Charles L.; Miranda, Edgar I.; Rivera, Isaac; Kabalka, George.

In: Tetrahedron Letters, Vol. 31, No. 33, 01.01.1990, p. 4677-4680.

Research output: Contribution to journalArticle

Soderquist, John A. ; Anderson, Charles L. ; Miranda, Edgar I. ; Rivera, Isaac ; Kabalka, George. / Essentially homochiral 1-silyl alcohols from the reduction of aliphatic acylsilanes with chlorodiisopinocampheylborane. In: Tetrahedron Letters. 1990 ; Vol. 31, No. 33. pp. 4677-4680.
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